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Research Paper Volume 12, Issue 10 pp 9915—9934

ZNF139/circZNF139 promotes cell proliferation, migration and invasion via activation of PI3K/AKT pathway in bladder cancer

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Figure 7. ZNF139 and its circRNA (circZNF139) activates PI3K/AKT signaling pathway in BC cells. (A) The expression of AKT in ZNF139-altered and ZNF139-unaltered groups in three datasets as analyzed in cBioPortal (http://cbioportal.org) database. (B–C) The protein levels of AKT, p-AKT, and PI3K in UC3 and 5637 cells treated with 3.1-ZNF139, si1-ZNF139, si2-ZNF139, 3.1-circZNF139, si1-circZNF139, si2-circZNF139 or matched controls (3.1/NC) were determined by western blot assays, respectively. ZNF139/ZKSCAN1, zinc finger with KRAB and SCAN domains 1; circ, circular; si, small interfering; NC, negative control.