miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of <i>Src</i>-mediated MAPK signaling pathway in ischemic stroke

Runhui Tian; Bo Wu; Cong Fu; Kaimin Guo

doi:doi:10.18632/aging.103301

← Back

This article is currently undergoing investigation.

Research Paper Volume 12, Issue 11 pp 10873—10895

miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in ischemic stroke

Figure 10. Downregulation of miR-137 increases oxidative stress and inflammatory response in brain tissues from MCAO mice. (A) ROS content in brain tissues from miR-137^-/- mice after staining with a DCFH-DA fluorescently-labeled probe; (B) TNF-α, IL-1, IL-6, IL-17 and IL-10 expression in brain tissues from miR-137^-/- mice using ELISA. Data are expressed as mean ± standard deviation and compared by one-way ANOVA, followed by Tukey's post hoc test. * p < 0.05 vs. control group (sham-operated wild-type mice); # p < 0.05 vs. MCAO group (wild-type mouse models of MCAO). N = 15.