miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of <i>Src</i>-mediated MAPK signaling pathway in ischemic stroke

Runhui Tian; Bo Wu; Cong Fu; Kaimin Guo

doi:doi:10.18632/aging.103301

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This article is currently undergoing investigation.

Research Paper Volume 12, Issue 11 pp 10873—10895

miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in ischemic stroke

Figure 13. Up-regulation of miR-137 or inhibition of Src inhibits the secretion of inflammatory cytokines and the degree of oxidative stress in astrocytes. (A) The expression of inflammatory markers in astrocytes using ELISA; (B) quantitation of ROS in astrocytes for each treatment group using the DCFH-DA fluorescent probe. Measurement data were expressed as mean ± standard deviation and compared using one-way ANOVA, followed by Tukey's post hoc test. * p < 0.05 vs. normal astrocytes; # p < 0.05 vs. OGD-induced astrocytes treated with negative controls; & p < 0.05 vs. astrocytes treated with miR-137 inhibitor. The experiment was repeated 3 times independently.