miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of <i>Src</i>-mediated MAPK signaling pathway in ischemic stroke

Runhui Tian; Bo Wu; Cong Fu; Kaimin Guo

doi:doi:10.18632/aging.103301

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This article is currently undergoing investigation.

Research Paper Volume 12, Issue 11 pp 10873—10895

miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in ischemic stroke

Figure 15. A model depicting the mechanism by which miR-137, Src, and MAPK signaling interact to regulate the response to ischemic stroke. miR-137 targets the Src gene resulting in the inactivation of the MAPK signaling pathway and reducing the inflammatory response and oxidative stress, thus alleviating ischemic stroke.