miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of <i>Src</i>-mediated MAPK signaling pathway in ischemic stroke

Runhui Tian; Bo Wu; Cong Fu; Kaimin Guo

doi:doi:10.18632/aging.103301

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This article is currently undergoing investigation.

Research Paper Volume 12, Issue 11 pp 10873—10895

miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in ischemic stroke

Figure 5. Knockout of the Src gene alleviates cerebral infarction, and improves neuron functions and learning and memory abilities in MCAO mice. (A) neurological function score of Src^-/- mice. (B) rate of left limb fault step in Src^-/- mice in the foot-fault test; (C) latency period and number of errors of Src^-/- mice during the step-down test; (D) the volume of infarct in Src^-/- mice after TTC staining; (E) the number of neurons in Src^-/- mice using Nissl staining (× 400). Measurement data are expressed as mean ± standard deviation and compared using one-way ANOVA, followed by Tukey's post hoc test. * p < 0.05 vs. control group (sham-operated wild-type mice); # p < 0.05 vs. MCAO group (wild-type mouse models of MCAO). N = 15.