miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of <i>Src</i>-mediated MAPK signaling pathway in ischemic stroke

Runhui Tian; Bo Wu; Cong Fu; Kaimin Guo

doi:doi:10.18632/aging.103301

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This article is currently undergoing investigation.

Research Paper Volume 12, Issue 11 pp 10873—10895

miR-137 prevents inflammatory response, oxidative stress, neuronal injury and cognitive impairment via blockade of Src-mediated MAPK signaling pathway in ischemic stroke

Figure 8. Src is a target gene of miR-137. (A) binding site prediction for miR-137: The 3’UTR of Src was analyzed using microRNA.org; (B) identification of the interaction between miR-137 and Src using dual-luciferase reporter assay; (C) miR-137 expression in the brain tissues of MCAO mice visualized by in situ hybridization (× 200). All measurement data were expressed as mean ± standard deviation and the differences between two groups were compared by independent sample t-test. * p < 0.05 vs. control cells. N = 15.