Long noncoding RNA SBF2-AS1 contributes to the growth and metastatic phenotypes of NSCLC via regulating miR-338-3p/ADAM17 axis

Qi Chen; Sheng Min Guo; Hou Qiang Huang; Guo Ping Huang; Yi Li; Zi Hui Li; Run Huang; Lu Xiao; Chun Rong Fan; Qing Yuan; Si Lin Zheng

doi:doi:10.18632/aging.103332

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Research Paper Volume 12, Issue 18 pp 17902—17920

Long noncoding RNA SBF2-AS1 contributes to the growth and metastatic phenotypes of NSCLC via regulating miR-338-3p/ADAM17 axis

Figure 7. ADAM17 is overexpressed in NSCLC. (A) IHC staining of ADAM17 in NSCLC and non-cancerous tissue. (B) qRT-PCR analysis of ADAM17 expression in NSCLC tissues and non-cancerous tissues (C) The expression levels of ADAM17 in patients with different stage. ^**P<0.01 compared with I-II stage. (D) The expression levels of ADAM17 in patients with or without metastasis. ^**P<0.01 compared with no metastasis. (E) Western blotting analysis of ADAM17 expression in human bronchial epithelial cell BEAS-2B and NSCLC cell lines (A549, H1650 and H1975). ^**P<0.01 compared with BEAS-2B. (F) High ADAM17 was a predictor for poor overall survival of NSCLC patients as analyzed using Kaplan-Meier plotter website.