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The cover features Figure 6 "Optical redox imaging of old mouse muscles.“ from Zhang et al.

Volume 12, Issue 18

30 September, 2020
pp 17754—18790

About the Cover

The cover features Figure 6 "Optical redox imaging of old mouse muscles.“ from Zhang et al.


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Editorials

The brain-gut axis of longevity

Anubhuti Dixit, Varsha Singh,
https://doi.org/10.18632/aging.103996 pp 17754—17755
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Aging during C. elegans L1 quiescence

Alejandro Mata-Cabana, Francisco Javier Romero-Expósito, María Olmedo,
https://doi.org/10.18632/aging.104027 pp 17756—17758
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Inflamm-ageing or inflammasom-ageing as independent events

Mario D. Cordero, Jesús Ruiz-Cabello,
https://doi.org/10.18632/aging.104108 pp 17759—17760
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Priority Research Papers

An ordered assembly of MYH glycosylase, SIRT6 protein deacetylase, and Rad9-Rad1-Hus1 checkpoint clamp at oxidatively damaged telomeres

Jun Tan, Xiangyu Wang, Bor-Jang Hwang, Rex Gonzales, Olivia Konen, Li Lan, A-Lien Lu,
https://doi.org/10.18632/aging.103934 pp 17761—17785
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Rapamycin maintains NAD+/NADH redox homeostasis in muscle cells

Zhigang Zhang, He N. Xu, Siyu Li, Antonio Davila Jr, Karthikeyani Chellappa, James G. Davis, Yuxia Guan, David W. Frederick, Weiqing Chu, Huaqing Zhao, Lin Z. Li, Joseph A. Baur,
https://doi.org/10.18632/aging.103954 pp 17786—17799
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p21 can be a barrier to ferroptosis independent of p53

Divya Venkatesh, Brent R. Stockwell, Carol Prives,
https://doi.org/10.18632/aging.103961 pp 17800—17814
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Research Papers

Alzheimer’s disease as a systems network disorder: chronic stress/dyshomeostasis, innate immunity, and genetics

Alexei Kurakin, Dale E. Bredesen,
https://doi.org/10.18632/aging.103883 pp 17815—17844
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Metformin improves cognition of aged mice by promoting cerebral angiogenesis and neurogenesis

Xiaoqi Zhu, Junyan Shen, Shengyu Feng, Ce Huang, Zhongmin Liu, Yi Eve Sun, Hailiang Liu,
https://doi.org/10.18632/aging.103693 pp 17845—17862
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Epigenetic mutation load is weakly correlated with epigenetic age acceleration

Qi Yan, Kimberly C. Paul, Ake T. Lu, Cynthia Kusters, Alexandra M. Binder, Steve Horvath, Beate Ritz,
https://doi.org/10.18632/aging.103950 pp 17863—17894
View Abstract PDF Full-Text How to Cite Special Collection on Steve Horvath's Publications in Aging (Albany NY)

Developmentally-programmed cellular senescence is conserved and widespread in zebrafish

Sabela Da Silva-Álvarez, Jorge Guerra-Varela, Daniel Sobrido-Cameán, Ana Quelle, Antón Barreiro-Iglesias, Laura Sánchez, Manuel Collado,
https://doi.org/10.18632/aging.103968 pp 17895—17901
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Long noncoding RNA SBF2-AS1 contributes to the growth and metastatic phenotypes of NSCLC via regulating miR-338-3p/ADAM17 axis

Qi Chen, Sheng Min Guo, Hou Qiang Huang, Guo Ping Huang, Yi Li, Zi Hui Li, Run Huang, Lu Xiao, Chun Rong Fan, Qing Yuan, Si Lin Zheng,
https://doi.org/10.18632/aging.103332 pp 17902—17920
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circKIF4A sponges miR-127 to promote ovarian cancer progression

Shunliang Sheng, Yi Hu, Furong Yu, Wenjuan Tong, Shufen Wang, Yanlin Cai, Jiayu Zhu,
https://doi.org/10.18632/aging.103389 pp 17921—17929
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Modulating redox homeostasis and cellular reprogramming through inhibited methylenetetrahydrofolate dehydrogenase 2 enzymatic activities in lung cancer

Chun-Hao Chan, Chia-Yu Wu, Navneet Kumar Dubey, Hong-Jian Wei, Jui-Hua Lu, Samantha Mao, Joy Liang, Yu-Hsuan Liang, Hsin-Chung Cheng, Win-Ping Deng,
https://doi.org/10.18632/aging.103471 pp 17930—17947
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Constructing a global transcriptional regulatory landscape for early non-small cell lung cancer to identify hub genes and key pathways

Jianlong Bu, Pinyi Zhang, Kaibin Zhu, Yubo Yan, Bowen Shi, Junfeng Wang, Shidong Xu,
https://doi.org/10.18632/aging.103475 pp 17948—17957
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Prognostic landscape of tumor-infiltrating immune cells and immune-related genes in the tumor microenvironment of gastric cancer

Shichao Zhang, Zhu Zeng, Yongfen Liu, Jiangtao Huang, Jinhua Long, Yun Wang, Xiaoyan Peng, Zuquan Hu, Yan Ouyang,
https://doi.org/10.18632/aging.103519 pp 17958—17975
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Prothrombotic effects of high uric acid in mice via activation of MEF2C-dependent NF-κB pathway by upregulating let-7c

Xiaoyu Cheng, Tian Liu, Lidan Ma, Zhen Liu, Ying Xin, Zhaotong Jia, Ying Chen, Changgui Li, Ruixia Sun,
https://doi.org/10.18632/aging.103540 pp 17976—17989
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SIRT1 activation by minocycline on regulation of microglial polarization homeostasis

Ling-Hsuan Wu, Bor-Ren Huang, Sheng-Wei Lai, Chingju Lin, Hsiao-Yun Lin, Liang-Yo Yang, Dah-Yuu Lu,
https://doi.org/10.18632/aging.103542 pp 17990—18007
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Pre-incubation with human umbilical cord derived mesenchymal stem cells-exosomes prevents cisplatin-induced renal tubular epithelial cell injury

Zongying Li, Shuyi Cao,
https://doi.org/10.18632/aging.103545 pp 18008—18018
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Long non-coding RNA AGAP2-AS1 increases the invasiveness of papillary thyroid cancer

Liang Shao, Wei Sun, Hao Zhang, Ping Zhang, Zhihong Wang, Wenwu Dong, Liang He, Ting Zhang, Yuan Qin,
https://doi.org/10.18632/aging.103570 pp 18019—18032
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Insulin sensitivity in long-lived growth hormone-releasing hormone knockout mice

Fang Zhang, Mert Icyuz, Zhenghui Liu, Michael Fitch, Liou Y. Sun,
https://doi.org/10.18632/aging.103588 pp 18033—18051
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Caloric restriction alleviates aging-related fibrosis of kidney through downregulation of miR-21 in extracellular vesicles

Jin-rui Liu, Guang-yan Cai, Yi-chun Ning, Jing-chao Wang, Yang Lv, Ya-nan Guo, Bo Fu, Quan Hong, Xue-feng Sun, Xiang-mei Chen,
https://doi.org/10.18632/aging.103591 pp 18052—18072
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MiR-141-3p ameliorates RIPK1-mediated necroptosis of intestinal epithelial cells in necrotizing enterocolitis

Xiang Li, Ying Wang, Yijiang Wang, Xingbo He,
https://doi.org/10.18632/aging.103608 pp 18073—18083
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RAI14 silencing suppresses progression of esophageal cancer via the STAT3 pathway

Jianlin Wang, Yun Cai, Judong Luo, Zhiqiang Sun, Jingping Yu, Feng Yan, Xia He,
https://doi.org/10.18632/aging.103613 pp 18084—18098
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Early-life exposure to bisphenol A and reproductive-related outcomes in rodent models: a systematic review and meta-analysis

Xiaohan Ren, Tongtong Zhang, Xinglin Chen, Xiyi Wei, Ye Tian, Guangyao Li, Xu Zhang, Wei Zhang, Zebing You, Shangqian Wang, Chao Qin,
https://doi.org/10.18632/aging.103620 pp 18099—18126
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GHR knockdown enhances the sensitivity of HCC cells to sorafenib

Shuang Gao, Qianwen Ni, Xiuli Wu, Tieliu Cao,
https://doi.org/10.18632/aging.103625 pp 18127—18136
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The clinicopathological characteristics and genetic alterations between younger and older gastric cancer patients with curative surgery

Chew-Wun Wu, Ming-Huang Chen, Kuo-Hung Huang, Shih-Ching Chang, Wen-Liang Fang, Chien-Hsing Lin, Yee Chao, Su-Shun Lo, Anna Fen-Yau Li, Yi-Ming Shyr,
https://doi.org/10.18632/aging.103627 pp 18137—18150
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Distant metastasis prediction via a multi-feature fusion model in breast cancer

Wenjuan Ma, Xin Wang, Guijun Xu, Zheng Liu, Zhuming Yin, Yao Xu, Haixiao Wu, Vladimir P. Baklaushev, Karl Peltzer, Henian Sun, Natalia V. Kharchenko, Lisha Qi, Min Mao, Yanbo Li, Peifang Liu, Vladimir P. Chekhonin, Chao Zhang,
https://doi.org/10.18632/aging.103630 pp 18151—18162
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Bioinformatics analysis of the clinical value and potential mechanisms of AHNAK2 in papillary thyroid carcinoma

Zhenyu Xie, Yu Lun, Xin Li, Yuzhen He, Song Wu, Shiyue Wang, Jianjian Sun, Yuchen He, Jian Zhang,
https://doi.org/10.18632/aging.103645 pp 18163—18180
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NLRP3 activation in endothelia promotes development of diabetes-associated atherosclerosis

Dong Huang, Wei Gao, Xin Zhong, Junbo Ge,
https://doi.org/10.18632/aging.103666 pp 18181—18191
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MicroRNA-216a-3p promotes sorafenib sensitivity in hepatocellular carcinoma by downregulating MAPK14 expression

Zhong Wan, Tingyu Liu, Liang Wang, Rong Wang, Hai Zhang,
https://doi.org/10.18632/aging.103670 pp 18192—18208
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piR-19166 inhibits migration and metastasis through CTTN/MMPs pathway in prostate carcinoma

Tingyue Qi, Haiyan Cao, Hongguang Sun, Hao Feng, Nianfeng Li, Chenghai Wang, Lei Wang,
https://doi.org/10.18632/aging.103677 pp 18209—18220
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High pulse pressure is a risk factor for prodromal Alzheimer’s disease: a longitudinal study

Wen-Yan Shi, Zuo-Teng Wang, Fu-Rong Sun, Ya-Hui Ma, Wei Xu, Xue-Ning Shen, Qiang Dong, Lan Tan, Jin-Tai Yu, Yang Yu, Alzheimer’s Disease Neuroimaging Initiative,
https://doi.org/10.18632/aging.103678 pp 18221—18237
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The mitochondrial-targeted peptide SBT-20 ameliorates inflammation and oxidative stress in chronic renal failure

Lina Sun, Haiping Xu, Yunfei Wang, Xiaoying Ma, Yan Xu, Fuyun Sun,
https://doi.org/10.18632/aging.103681 pp 18238—18250
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Transcriptomic analysis reveals gender differences in gene expression profiling of the hypothalamus of rhesus macaque with aging

Yong Fan, Congru Li, Wendi Pei, Tao Tan, Rong Li, Jie Qiao, Yang Yu,
https://doi.org/10.18632/aging.103682 pp 18251—18273
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MSC-derived exosomes promote recovery from traumatic brain injury via microglia/macrophages in rat

Yunfei Chen, Jing Li, Baitao Ma, Na Li, Shihua Wang, Zhao Sun, Chunling Xue, Qin Han, Junji Wei, Robert Chunhua Zhao,
https://doi.org/10.18632/aging.103692 pp 18274—18296
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Glioblastoma cell differentiation trajectory predicts the immunotherapy response and overall survival of patients

Zihao Wang, Xiaopeng Guo, Lu Gao, Yu Wang, Wenbin Ma, Bing Xing,
https://doi.org/10.18632/aging.103695 pp 18297—18321
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A two-gene-based prognostic signature for pancreatic cancer

Shuyi Zhou, Yuanliang Yan, Xi Chen, Shuangshuang Zeng, Jie Wei, Xiang Wang, Zhicheng Gong, Zhijie Xu,
https://doi.org/10.18632/aging.103698 pp 18322—18342
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Modeling mtDNA hypermethylation vicious circle mediating Aβ-induced endothelial damage memory in HCMEC/D3 cell

HaoChen Liu, Hong Zhang, Yixuan Zhang, Sheng Xu, Huimin Zhao, Hua He, XiaoQuan Liu,
https://doi.org/10.18632/aging.103699 pp 18343—18362
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A 12-immune cell signature to predict relapse and guide chemotherapy for stage II colorectal cancer

Xianglong Tian, Xiaoqiang Zhu, Wenying Meng, Shiguang Bai, Min Shi, Shihao Xiang, Chen Zhao, Yugang Wang,
https://doi.org/10.18632/aging.103707 pp 18363—18383
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p38γ overexpression promotes osteosarcoma cell progression

Ce Shi, Wei-Nan Cheng, Yin Wang, Da-Zhuang Li, Li-Na Zhou, Yu-Cheng Zhu, Xiao-Zhong Zhou,
https://doi.org/10.18632/aging.103708 pp 18384—18395
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Elevated serum IL-21 levels are associated with stable immune status in kidney transplant recipients and a mouse model of kidney transplantation

Luying Guo, Junhao Lv, Jian Zhang, Hao Deng, Shi Feng, Shuaihui Liu, Pengpeng Yan, Jingyi Zhou, Hui Chen, Meifang Wang, Qin Zhou, Huiping Wang, Jianghua Chen, Yu Kuang, Jia Shen, Rending Wang,
https://doi.org/10.18632/aging.103713 pp 18396—18414
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Association of vitamin C intake with breast cancer risk and mortality: a meta-analysis of observational studies

Dai Zhang, Peng Xu, Yiche Li, Bajin Wei, Si Yang, Yi Zheng, Lijuan Lyu, Yujiao Deng, Zhen Zhai, Na Li, Nan Wang, Jun Lyu, Zhijun Dai,
https://doi.org/10.18632/aging.103769 pp 18415—18435
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Nudt21-mediated alternative polyadenylation of HMGA2 3′-UTR impairs stemness of human tendon stem cell

Yangbai Sun, Hua Chen, Hui Ye, Wenqing Liang, Kun-kuan Lam, Biao Cheng, Yong Lu, Chaoyin Jiang,
https://doi.org/10.18632/aging.103771 pp 18436—18452
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A newly defined risk signature, consisting of three m6A RNA methylation regulators, predicts the prognosis of ovarian cancer

Lili Fan, Ying Lin, Han Lei, Guang Shu, Liuer He, Zhipeng Yan, Hai Rihan, Gang Yin,
https://doi.org/10.18632/aging.103811 pp 18453—18475
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YTHDF2 correlates with tumor immune infiltrates in lower-grade glioma

Xiangan Lin, Zhichao Wang, Guangda Yang, Guohua Wen, Hailiang Zhang,
https://doi.org/10.18632/aging.103812 pp 18476—18500
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D-galactose induces senescence of glioblastoma cells through YAP-CDK6 pathway

Xingxing Xu, Xiya Shen, Wenjin Feng, Danlu Yang, Lingting Jin, Jiaojiao Wang, Mianxian Wang, Zhang Ting, Feng Xue, Jingjing Zhang, Chaobo Meng, Roumeng Chen, Xinru Zheng, Leilei Du, Lina Xuan, Ying Wang, Tian Xie, Zhihui Huang,
https://doi.org/10.18632/aging.103819 pp 18501—18521
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GPA peptide inhibits NLRP3 inflammasome activation to ameliorate colitis through AMPK pathway

Zhao Deng, Jiangjin Ni, Xiaoyu Wu, Hongkui Wei, Jian Peng,
https://doi.org/10.18632/aging.103825 pp 18522—18544
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MiR-520d-5p modulates chondrogenesis and chondrocyte metabolism through targeting HDAC1

Jiajia Lu, Zhibin Zhou, Bin Sun, Bin Han, Qiang Fu, Yaguang Han, Wang Yuan, Zeng Xu, Aimin Chen,
https://doi.org/10.18632/aging.103831 pp 18545—18560
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Chetomin rescues pathogenic phenotype of LRRK2 mutation in drosophila

Ling Ling Chua, Patrick Ho, Joanne Toh, Eng-King Tan,
https://doi.org/10.18632/aging.103843 pp 18561—18570
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Characterization of LncRNA SNHG22 as a protector of NKIRAS2 through miR-4492 binding in osteosarcoma

Huo-Liang Zheng, Run-Ze Yang, Wen-Ning Xu, Tao Liu, Peng-Bo Chen, Xin-Feng Zheng, Bo Li, Lei-Sheng Jiang, Sheng-Dan Jiang,
https://doi.org/10.18632/aging.103849 pp 18571—18587
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Lipopolysaccharide upregulates miR-132/212 in Hirschsprung-associated enterocolitis, facilitating pyroptosis by activating NLRP3 inflammasome via targeting Sirtuin 1 (SIRT1)

Hongxing Li, Lingling Zhou, Zhengke Zhi, Xiurui Lv, Zhonghong Wei, Xin Zhang, Weibing Tang, Meiling Tong,
https://doi.org/10.18632/aging.103852 pp 18588—18602
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Muscle defects due to perturbed somite segmentation contribute to late adult scoliosis

Laura Lleras-Forero, Elis Newham, Stefan Teufel, Koichi Kawakami, Christine Hartmann, Chrissy L. Hammond, Robert D. Knight, Stefan Schulte-Merker,
https://doi.org/10.18632/aging.103856 pp 18603—18621
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Asymmetrical nigral iron accumulation in Parkinson’s disease with motor asymmetry: an explorative, longitudinal and test-retest study

Xiaojun Guan, Tao Guo, Cheng Zhou, Jingjing Wu, Ting Gao, Xueqin Bai, Hongjiang Wei, Yuyao Zhang, Min Xuan, Quanquan Gu, Peiyu Huang, Chunlei Liu, Baorong Zhang, Jiali Pu, Zhe Song, Yaping Yan, Feng Cui, Minming Zhang, Xiaojun Xu,
https://doi.org/10.18632/aging.103870 pp 18622—18634
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Visfatin increases ICAM-1 expression and monocyte adhesion in human osteoarthritis synovial fibroblasts by reducing miR-320a expression

Yat-Yin Law, Yu-Min Lin, Shan-Chi Liu, Min-Huan Wu, Wen-Hui Chung, Chun-Hao Tsai, Yi-Chin Fong, Chih-Hsin Tang, Chin-Kun Wang,
https://doi.org/10.18632/aging.103889 pp 18635—18648
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Knockdown of TXNDC9 induces apoptosis and autophagy in glioma and mediates cell differentiation by p53 activation

Tingting Zheng, Keke Chen, Xue Zhang, Huanhuan Feng, Yu Shi, Li Liu, Jun Zhang, Yun Chen,
https://doi.org/10.18632/aging.103915 pp 18649—18659
View Abstract PDF Full-Text How to Cite Special Collection on p53 Part 2

β-lactolin increases cerebral blood flow in dorsolateral prefrontal cortex in healthy adults: a randomized controlled trial

Yasuhisa Ano, Keiko Kobayashi, Mamoru Hanyuda, Ryuta Kawashima,
https://doi.org/10.18632/aging.103951 pp 18660—18675
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Identification of genomic alterations and associated transcriptomic profiling reveal the prognostic significance of MMP14 and PKM2 in patients with pancreatic cancer

Haiwei Wang, Xinrui Wang, Liangpu Xu, Yingying Lin, Ji Zhang, Hua Cao,
https://doi.org/10.18632/aging.103958 pp 18676—18692
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Resemblance and differences in dietary restriction nephroprotective mechanisms in young and old rats

Nadezda V. Andrianova, Ljubava D. Zorova, Irina B. Pevzner, Vasily A. Popkov, Valery P. Chernikov, Denis N. Silachev, Egor Y. Plotnikov, Dmitry B. Zorov,
https://doi.org/10.18632/aging.103960 pp 18693—18715
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Identification of robust genetic signatures associated with lipopolysaccharide-induced acute lung injury onset and astaxanthin therapeutic effects by integrative analysis of RNA sequencing data and GEO datasets

Kaimin Mao, Wei Geng, Yuhan Liao, Ping Luo, Hua Zhong, Pei Ma, Juanjuan Xu, Shuai Zhang, Qi Tan, Yang Jin,
https://doi.org/10.18632/aging.104042 pp 18716—18740
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A comprehensive analysis of the fatal toxic effects associated with CD19 CAR-T cell therapy

Changjing Cai, Diya Tang, Ying Han, Edward Shen, Omar Abdihamid, Cao Guo, Hong Shen, Shan Zeng,
https://doi.org/10.18632/aging.104058 pp 18741—18753
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Reviews

COVID-19
Neurological manifestations in COVID-19 and its possible mechanism

Xiaojia Tang, Yuhan Luo, Yuxia Song, Hongyang Fan, Sisi Dong, Peipei Liu, Yingzhu Chen,
https://doi.org/10.18632/aging.103732 pp 18754—18764
View Abstract PDF Full-Text How to Cite Special Collection on COVID-19 Part 2

Psychological aging, depression, and well-being

Maria Mitina, Sergey Young, Alex Zhavoronkov,
https://doi.org/10.18632/aging.103880 pp 18765—18777
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COVID-19
SARS-CoV-2, immunosenescence and inflammaging: partners in the COVID-19 crime

Renato Domingues, Alice Lippi, Cristian Setz, Tiago F. Outeiro, Anita Krisko,
https://doi.org/10.18632/aging.103989 pp 18778—18789
View Abstract PDF Full-Text How to Cite Special Collection on COVID-19 Part 2

Correction

Correction for: hsa_circRNA6448-14 promotes carcinogenesis in esophageal squamous cell carcinoma

Yaowen Zhang, Xiang Yuan, Ning Yue, Lidong Wang, Junqi Liu, Ningtao Dai, Haijun Yang, Ruitai Fan, Fuyou Zhou,
https://doi.org/10.18632/aging.104164 pp 18790
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