Research Paper Volume 12, Issue 13 pp 12869—12895
miR-183-5p alleviates early injury after intracerebral hemorrhage by inhibiting heme oxygenase-1 expression
Figure 2. Administration of miR-183-5p reduced neurologic deficits, blood-brain barrier permeability, and brain injury volume after intracerebral hemorrhaging (ICH). (A) Left: representative images of a series of brain slices from different groups at 3 days after ICH. Right: quantitative analysis of hematoma volume. n = 8/group. (B) Left: representative images of brain slices from different groups at 3 days after ICH stained with Evans blue (EB). Right: quantitative analysis of EB extravasation. n = 8/group. (C) Brain water content in the different groups at 3 days after ICH. n = 8/group. Ipsi-Stri, ipsilateral striatum; Con-Stri, contralateral striatum; Cerebel, cerebellum. (D) Neurologic deficit scores of mice at 3 days after ICH. n = 24/group. Values are presented as the mean ± standard deviation. *P < 0.05 vs. the ICH group.