Research Paper Volume 12, Issue 13 pp 12869—12895
miR-183-5p alleviates early injury after intracerebral hemorrhage by inhibiting heme oxygenase-1 expression
Figure 6. miRNA-183-5p affected microglial survival by targeting heme oxygenase-1 (HO-1) after intracerebral hemorrhage (ICH). (A) Left: representative immunofluorescence images of HO-1 in Iba-1–positive microglia at 3 days after ICH. Right: percentage of both Iba-1– and HO-1–positive cells in Iba-1–positive microglia. Scale bars = 50 μm, n = 8/group. *P < 0.05 vs. the ICH group. (B) Above: representative immunofluorescence images of HO-1 in BV2 microglia from different groups at 24 hours after hemin treatment. Below: percentage of HO-1–positive BV2 microglia. Scale bars = 50 μm, n = 3/group. *P < 0.05 vs. the hemin group. ZnPP, zinc protoporphyrin IX; CoPP, cobalt protoporphyrin IX.