Research Paper Volume 12, Issue 13 pp 12869—12895
miR-183-5p alleviates early injury after intracerebral hemorrhage by inhibiting heme oxygenase-1 expression
Figure 8. The experimental design. Sham group, sham operation group; ICH group, collagenase-induced intracerebral hemorrhage group; miRNA-seq, miRNA sequencing; miR-183-5p, microRNA-183-5p; HO-1, heme oxygenase-1; ICH 1 d, 3 d, 7 d, 14 d, 28 d groups, 1 day, 3 days, 7 days, 14 days, 28 days after collagenase-induced intracerebral hemorrhage groups; ZnPP, HO-1 inhibitor zinc protoporphyrin IX; Nrf2-/-, nuclear factor erythroid 2-related factor knockout; CoPP, HO-1 inducer cobalt protoporphyrin IX; tBHQ, Nrf2 activator tert-butylhydroquinone.