Research Paper Volume 12, Issue 12 pp 12032—12050

Figure 3. Aged CD70⁺ T cells show a phenotype of over activation. Flow cytometry analysis of percentage of HLA-DR⁺ CD38^hi cells (A–B), and expression of CD28 (C–D) and CD27 (E–F) on CD70^- vs. CD70⁺ CD4⁺ and CD8⁺ T cells from elderly individuals (61-80 years, n = 17). Representative flow data or histograms (left) and plots (right) display the expression of the above receptors on CD70^- vs. CD70⁺ cells (gated with CD4⁺ or CD8⁺ T cells). The p-values were obtained by paired t-test (HLA-DR⁺CD38^hi [CD4⁺ T cells], CD28, CD27) or Wilcoxon matched-pairs signed rank test (HLA-DR⁺CD38^hi [CD8⁺ T cells]). ***p < 0.001.