Sarallah Rezazadeh, David Yang, Seyed Ali Biashad, Denis Firsanov, Masaki Takasugi, Michael Gilbert, Gregory Tombline, Natarajan V. Bhanu, Benjamin A. Garcia, Andrei Seluanov, Vera Gorbunova,
Rezazadeh S, Yang D, Biashad SA, Firsanov D, Takasugi M, Gilbert M, Tombline G, Bhanu NV, Garcia BA, Seluanov A, Gorbunova V, . SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair. . 12:11165-11184. https://doi.org/10.18632/aging.103567
Kelvin Yen, Hemal H. Mehta, Su-Jeong Kim, YanHe Lue, James Hoang, Noel Guerrero, Jenna Port, Qiuli Bi, Gerardo Navarrete, Sebastian Brandhorst, Kaitlyn Noel Lewis, Junxiang Wan, Ronald Swerdloff, Julie A. Mattison, Rochelle Buffenstein, Carrie V. Breton, Christina Wang, Valter Longo, Gil Atzmon, Douglas Wallace, Nir Barzilai, Pinchas Cohen,
Yen K, Mehta HH, Kim S, Lue Y, Hoang J, Guerrero N, Port J, Bi Q, Navarrete G, Brandhorst S, Lewis KN, Wan J, Swerdloff R, et al, . The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan. . 12:11185-11199. https://doi.org/10.18632/aging.103534
Elena Alcalde-Estévez, Ana Asenjo-Bueno, Patricia Sosa, Gemma Olmos, Patricia Plaza, María Ángeles Caballero-Mora, Diego Rodríguez-Puyol, María Piedad Ruíz-Torres, Susana López-Ongil,
Alcalde-Estévez E, Asenjo-Bueno A, Sosa P, Olmos G, Plaza P, Caballero-Mora MÁ, Rodríguez-Puyol D, Ruíz-Torres MP, López-Ongil S, . Endothelin-1 induces cellular senescence and fibrosis in cultured myoblasts. A potential mechanism of aging-related sarcopenia. . 12:11200-11223. https://doi.org/10.18632/aging.103450
Huang Y, Cai C, Zang J, Xie J, Xu D, Zheng F, Zhan T, Huang K, Wang Y, Wang X, Hu Z, Deng Y, Xie Y, . Treatment strategies of hospitalized patients with coronavirus disease-19. . 12:11224-11237. https://doi.org/10.18632/aging.103370
Wan Y, Wu J, Ni L, Luo Q, Yuan C, Fan F, Liu H, Zhang C, Xiang Y, Xie Q, . Prognosis analysis of patients with mental disorders with COVID-19: a single-center retrospective study. . 12:11238-11244. https://doi.org/10.18632/aging.103371
Han Y, Zhang H, Mu S, Wei W, Jin C, Tong C, Song Z, Zha Y, Xue Y, Gu G, . Lactate dehydrogenase, an independent risk factor of severe COVID-19 patients: a retrospective and observational study. . 12:11245-11258. https://doi.org/10.18632/aging.103372
Huang X, Pearce R, Zhang Y, . De novo design of protein peptides to block association of the SARS-CoV-2 spike protein with human ACE2. . 12:11263-11276. https://doi.org/10.18632/aging.103416
Bock J, Ortea I, . Re-analysis of SARS-CoV-2-infected host cell proteomics time-course data by impact pathway analysis and network analysis: a potential link with inflammatory response. . 12:11277-11286. https://doi.org/10.18632/aging.103524
Sun J, Zhang W, Zou L, Liu Y, Li J, Kan X, Dai L, Shi Q, Yuan S, Yu W, Xu H, Gu W, Qi J, . Serum calcium as a biomarker of clinical severity and prognosis in patients with coronavirus disease 2019. . 12:11287-11295. https://doi.org/10.18632/aging.103526
Zhou Z, Zhang M, Wang Y, Zheng F, Huang Y, Huang K, Yu Q, Cai C, Chen D, Tian Y, Lei J, Xiao X, Clercq ED, et al, . Clinical characteristics of older and younger patients infected with SARS-CoV-2. . 12:11296-11305. https://doi.org/10.18632/aging.103535
Bousquet G, Falgarone G, Deutsch D, Derolez S, Lopez-Sublet M, Goudot F, Amari K, Uzunhan Y, Bouchaud O, Pamoukdjian F, . ADL-dependency, D-Dimers, LDH and absence of anticoagulation are independently associated with one-month mortality in older inpatients with Covid-19. . 12:11306-11313. https://doi.org/10.18632/aging.103583
Machin DR, Auduong Y, Gogulamudi VR, Liu Y, Islam MT, Lesniewski LA, Donato AJ, . Lifelong SIRT-1 overexpression attenuates large artery stiffening with advancing age. . 12:11314-11324. https://doi.org/10.18632/aging.103322
Ogura Y, Kitada M, Xu J, Monno I, Koya D, . CD38 inhibition by apigenin ameliorates mitochondrial oxidative stress through restoration of the intracellular NAD+/NADH ratio and Sirt3 activity in renal tubular cells in diabetic rats. . 12:11325-11336. https://doi.org/10.18632/aging.103410
Sierra-Ramirez A, López-Aceituno JL, Costa-Machado LF, Plaza A, Barradas M, Fernandez-Marcos PJ, . Transient metabolic improvement in obese mice treated with navitoclax or dasatinib/quercetin. . 12:11337-11348. https://doi.org/10.18632/aging.103607
Jiang S, Li H, Piao L, Jin Z, Liu J, Chen S, Liu LL, Shao Y, Zhong S, Wu B, Li W, Ren J, Zhang Y, et al, . Computational study on new natural compound inhibitors of indoleamine 2,3-dioxygenase 1. . 12:11349-11363. https://doi.org/10.18632/aging.103113
Zhou Z, Ma D, Li P, Wang P, Liu P, Wei D, Wang J, Qin Z, Fang Q, Wang J, . Sirt1 gene confers Adriamycin resistance in DLBCL via activating the PCG-1α mitochondrial metabolic pathway. . 12:11364-11385. https://doi.org/10.18632/aging.103174
Wang Z, Lin Y, Jin S, Wei T, Zheng Z, Chen W, . Bone marrow mesenchymal stem cells improve thymus and spleen function of aging rats through affecting P21/PCNA and suppressing oxidative stress. . 12:11386-11397. https://doi.org/10.18632/aging.103186
Yu S, Zhao Y, Zhang F, Li Y, Shen W, Sun Z, . Chestnut polysaccharides benefit spermatogenesis through improvement in the expression of important genes. . 12:11431-11445. https://doi.org/10.18632/aging.103205
Sun Q, Zeng J, Liu Y, Chen J, Zeng Q, Chen Y, Tu L, Chen P, Yang F, Zhang M, . microRNA-9 and -29a regulate the progression of diabetic peripheral neuropathy via ISL1-mediated sonic hedgehog signaling pathway. . 12:11446-11465. https://doi.org/10.18632/aging.103230
Jiang G, Shi L, Zheng X, Zhang X, Wu K, Liu B, Yan P, Liang X, Yu T, Wang Y, Cai X, . Androgen receptor affects the response to immune checkpoint therapy by suppressing PD-L1 in hepatocellular carcinoma. . 12:11466-11484. https://doi.org/10.18632/aging.103231
Zhang Q, Niu X, Tian L, Liu J, Niu R, Quan J, Yu J, Lin W, Qian Z, Zeng P, . CTRP13 attenuates the expression of LN and CAV-1 Induced by high glucose via CaMKKβ/AMPK pathway in rLSECs. . 12:11485-11499. https://doi.org/10.18632/aging.103234
Sun F, Wu K, Yao Z, Mu X, Zheng Z, Sun M, Wang Y, Liu Z, Zhu Y, . Long noncoding RNA LINC00963 induces NOP2 expression by sponging tumor suppressor miR-542-3p to promote metastasis in prostate cancer. . 12:11500-11516. https://doi.org/10.18632/aging.103236
Li S, Song F, Lei X, Li J, Li F, Tan H, . hsa_circ_0004018 suppresses the progression of liver fibrosis through regulating the hsa-miR-660-3p/TEP1 axis. . 12:11517-11529. https://doi.org/10.18632/aging.103257
Liu G, Zhou J, Piao Y, Zhao X, Zuo Y, Ji Z, . Hsa_circ_0085576 promotes clear cell renal cell carcinoma tumorigenesis and metastasis through the miR-498/YAP1 axis. . 12:11530-11549. https://doi.org/10.18632/aging.103300
Wang J, Pu J, Zhang Y, Yao T, Luo Z, Li W, Xu G, Liu J, Wei W, Deng Y, . Exosome-transmitted long non-coding RNA SENP3-EIF4A1 suppresses the progression of hepatocellular carcinoma. . 12:11550-11567. https://doi.org/10.18632/aging.103302
Shi Z, Wang R, Huang L, Chen X, Xu M, Zha D, Ma Y, . Integrative analysis of miRNAs-mRNAs reveals that miR-182 up-regulation contributes to proliferation and invasion of nasopharyngeal carcinoma by targeting PTEN. . 12:11568-11578. https://doi.org/10.18632/aging.103316
Chao X, Yi L, Lan LL, Wei HY, Wei D, . Long-term PM2.5 exposure increases the risk of non-small cell lung cancer (NSCLC) progression by enhancing interleukin-17a (IL-17a)-regulated proliferation and metastasis. . 12:11579-11602. https://doi.org/10.18632/aging.103319
Liu Z, Tao B, Fan S, Cui S, Pu Y, Qiu L, Xia H, Xu L, . Over-expression of microRNA-145 drives alterations in β-adrenergic signaling and attenuates cardiac remodeling in heart failure post myocardial infarction. . 12:11603-11622. https://doi.org/10.18632/aging.103320
Jin J, Liu H, Jin M, Li W, Xu H, Wei F, . Silencing of hsa_circ_0101145 reverses the epithelial-mesenchymal transition in hepatocellular carcinoma via regulation of the miR-548c-3p/LAMC2 axis. . 12:11623-11635. https://doi.org/10.18632/aging.103324
Zhu X, Luo C, Bu F, Lin K, Zhu Z, . Long non-coding RNA RP11-59H7.3 promotes cell proliferation and invasion metastasis in colorectal cancer by miR-139-5p/NOTCH1 axis. . 12:11653-11666. https://doi.org/10.18632/aging.103331
Chen C, Wei M, Wang C, Sun D, Liu P, Zhong X, Yu W, . Long noncoding RNA KCNQ1OT1 promotes colorectal carcinogenesis by enhancing aerobic glycolysis via hexokinase-2. . 12:11685-11697. https://doi.org/10.18632/aging.103334
Chen Y, Wang Y, Hu J, Tang Y, Tian Z, Hu W, Zeng F, Tan J, Dai Q, Hou Z, Luo F, Xu J, Dong S, . Epothilone B prevents lipopolysaccharide-induced inflammatory osteolysis through suppressing osteoclastogenesis via STAT3 signaling pathway. . 12:11698-11716. https://doi.org/10.18632/aging.103337
Dai H, Li M, Yang W, Sun X, Wang P, Wang X, Su J, Wang X, Hu X, Zhao M, . Resveratrol inhibits the malignant progression of hepatocellular carcinoma via MARCH1-induced regulation of PTEN/AKT signaling. . 12:11717-11731. https://doi.org/10.18632/aging.103338
Hu S, Shao Z, Zhang C, Chen L, Mamun AA, Zhao N, Cai J, Lou Z, Wang X, Chen J, . Chemerin facilitates intervertebral disc degeneration via TLR4 and CMKLR1 and activation of NF-kB signaling pathway. . 12:11732-11753. https://doi.org/10.18632/aging.103339
Zhuang Y, Wang S, Fei H, Ji F, Sun P, . miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and cytotoxicity. . 12:11754-11767. https://doi.org/10.18632/aging.103341
Zeng Z, Gong X, Hu Z, . L-3-n-butylphthalide attenuates inflammation response and brain edema in rat intracerebral hemorrhage model. . 12:11768-11780. https://doi.org/10.18632/aging.103342
Deng Z, Zhou L, Wang Y, Liao S, Huang Y, Shan Y, Tan S, Zeng Q, Peng L, Huang H, Lu Z, . Astrocyte-derived VEGF increases cerebral microvascular permeability under high salt conditions. . 12:11781-11793. https://doi.org/10.18632/aging.103348
Liu C, Li Z, Xu L, Shi Y, Zhang X, Shi S, Hou K, Fan Y, Li C, Wang X, Zhou L, Liu Y, Qu X, et al, . GALNT6 promotes breast cancer metastasis by increasing mucin-type O-glycosylation of α2M. . 12:11794-11811. https://doi.org/10.18632/aging.103349
Usama Khamis Hussein, Sang Hoon Ha, Asmaa Gamal Ahmed, Kyoung Min Kim, See-Hyoung Park, Chan Young Kim, Keun Sang Kwon, Zhongkai Zhang, Sang-A Lee, Ho Sung Park, Byung-Hyun Park, Ho Lee, Myoung Ja Chung, Woo Sung Moon, Myoung Jae Kang, Kyu Yun Jang,
Hussein UK, Ha SH, Ahmed AG, Kim KM, Park S, Kim CY, Kwon KS, Zhang Z, Lee S, Park HS, Park B, Lee H, Chung MJ, et al, . FAM83H and SCRIB stabilize β-catenin and stimulate progression of gastric carcinoma. . 12:11812-11834. https://doi.org/10.18632/aging.103351
Ji K, Wu L, Zhao W, Wu C, Xu Y, Duan J, Meng R, Yan F, Chen J, Wu D, Luo Y, Ji X, . Anticoagulation delay does not affect the functional outcome of cerebral venous thrombosis. . 12:11835-11842. https://doi.org/10.18632/aging.103353
Yao Z, Jia C, Tai Y, Liang H, Zhong Z, Xiong Z, Deng M, Zhang Q, . Serum exosomal long noncoding RNAs lnc-FAM72D-3 and lnc-EPC1-4 as diagnostic biomarkers for hepatocellular carcinoma. . 12:11843-11863. https://doi.org/10.18632/aging.103355
Chen S, Hu F, Wang D, Qin Z, Liang Y, Dai Y, . Prognosis and regulation of an adenylyl cyclase network in acute myeloid leukemia. . 12:11864-11877. https://doi.org/10.18632/aging.103357
Zhou X, Cai B, Hou X, Kang X, Xu X, Wang W, . Development and validation of a risk score for predicting mortality after resection of primary hepatocellular carcinoma. . 12:11878-11892. https://doi.org/10.18632/aging.103360
Deng G, Yin R, Guan Y, Liu C, Zheng P, Wei B, Wu J, Miao L, . Association of the NCAN-TM6SF2-CILP2-PBX4-SUGP1-MAU2 SNPs and gene-gene and gene-environment interactions with serum lipid levels. . 12:11893-11913. https://doi.org/10.18632/aging.103361
Jovia L. Nierenberg, Jiang He, Changwei Li, Xiaoying Gu, Mengyao Shi, Alexander C. Razavi, Xuenan Mi, Shengxu Li, Lydia A. Bazzano, Amanda H. Anderson, Hua He, Wei Chen, Jack M. Guralnik, Jason M. Kinchen, Tanika N. Kelly,
Nierenberg JL, He J, Li C, Gu X, Shi M, Razavi AC, Mi X, Li S, Bazzano LA, Anderson AH, He H, Chen W, Guralnik JM, et al, . Serum metabolites associate with physical performance among middle-aged adults: Evidence from the Bogalusa Heart Study. . 12:11914-11941. https://doi.org/10.18632/aging.103362
Wang C, Just A, Heiss J, Coull BA, Hou L, Zheng Y, Sparrow D, Vokonas PS, Baccarelli A, Schwartz J, . Biomarkers of aging and lung function in the normative aging study. . 12:11942-11966. https://doi.org/10.18632/aging.103363
Liu L, Hu J, Wang Y, Sun T, Zhou X, Li X, Ma F, . Establishment of a novel risk score model by comprehensively analyzing the immunogen database of bladder cancer to indicate clinical significance and predict prognosis. . 12:11967-11989. https://doi.org/10.18632/aging.103364
Mo J, Chen Z, Xu J, Wang A, Meng X, Zhao X, Li H, Wu S, Wang Y, . The impact of the cumulative burden of LDL-c and hs-CRP on cardiovascular risk: a prospective, population-based study. . 12:11990-12001. https://doi.org/10.18632/aging.103365
Wei F, Wang A, Wang Q, Han W, Rong R, Wang L, Liu S, Zhang Y, Dong C, Li Y, . Plasma endothelial cells-derived extracellular vesicles promote wound healing in diabetes through YAP and the PI3K/Akt/mTOR pathway. . 12:12002-12018. https://doi.org/10.18632/aging.103366
Wang D, Du J, Song Y, Wang B, Song R, Hao Y, Zeng Y, Xiao J, Zheng H, Zeng H, Zhao H, Kong Y, . CD70 contributes to age-associated T cell defects and overwhelming inflammatory responses. . 12:12032-12050. https://doi.org/10.18632/aging.103368
Song Y, Jin D, Chen J, Luo Z, Chen G, Yang Y, Liu X, . Identification of an immune-related long non-coding RNA signature and nomogram as prognostic target for muscle-invasive bladder cancer. . 12:12051-12073. https://doi.org/10.18632/aging.103369
Xu Z, Ke T, Zhang Y, Fu C, He W, . Agonism of GPR120 prevented IL-1β-induced reduction of extracellular matrix through SOX-9. . 12:12074-12085. https://doi.org/10.18632/aging.103375
Gong T, Li Y, Feng L, Fang M, Dai G, Huang X, Yang Y, Liu S, . CASC21, a FOXP1 induced long non-coding RNA, promotes colorectal cancer growth by regulating CDK6. . 12:12086-12106. https://doi.org/10.18632/aging.103376
Li M, Meng X, Li M, . MiR-126 promotes esophageal squamous cell carcinoma via inhibition of apoptosis and autophagy. . 12:12107-12118. https://doi.org/10.18632/aging.103379
Wang W, Wang B, Liu C, Yan J, Xiong X, Wang X, Yang J, Guo B, Huang C, . Serum proteomic predicts effectiveness and reveals potential biomarkers for complications in liver transplant patients. . 12:12119-12141. https://doi.org/10.18632/aging.103381
Zhou F, Xiong X, Li S, Liang J, Zhang X, Tian M, Li X, Gao M, Tang L, Li Y, . Enhanced autophagic retrograde axonal transport by dynein intermediate chain upregulation improves Aβ clearance and cognitive function in APP/PS1 double transgenic mice. . 12:12142-12159. https://doi.org/10.18632/aging.103382
Xin T, Lv W, Liu D, Jing Y, Hu F, . ROCK1 knockdown inhibits non-small-cell lung cancer progression by activating the LATS2-JNK signaling pathway. . 12:12160-12174. https://doi.org/10.18632/aging.103386
Chen Z, Mo J, Xu J, Wang A, Qin H, Zheng H, Liu L, Meng X, Li H, Wang Y, . Combined impact of body mass index and glycemic control on the efficacy of clopidogrel-aspirin therapy in patients with minor stroke or transient ischemic attack. . 12:12175-12186. https://doi.org/10.18632/aging.103394
Cao D, Chen M, Zhang Q, Zhou Y, Zhang M, Mai S, Zhang Y, Chen M, Li X, Wang H, . Identification of immunological subtypes of hepatocellular carcinoma with expression profiling of immune-modulating genes. . 12:12187-12205. https://doi.org/10.18632/aging.103395
Jiang W, Han T, Duan W, Dong Q, Hou W, Wu H, Wang Y, Jiang Z, Pei X, Chen Y, Li Y, Sun C, . Prenatal famine exposure and estimated glomerular filtration rate across consecutive generations: association and epigenetic mediation in a population-based cohort study in Suihua China. . 12:12206-12221. https://doi.org/10.18632/aging.103397
Yu H, Zhu X, Lin H, Pan H, Zhao F, Zhu M, Sun L, Chai W, Yao M, Yan M, . A new risk model comprising genes highly correlated with CD133 identifies different tumor-immune microenvironment subtypes impacting prognosis in hepatocellular carcinoma. . 12:12234-12250. https://doi.org/10.18632/aging.103409
Radenovic L, Nenadic M, Ułamek-Kozioł M, Januszewski S, Czuczwar SJ, Andjus PR, Pluta R, . Heterogeneity in brain distribution of activated microglia and astrocytes in a rat ischemic model of Alzheimer’s disease after 2 years of survival. . 12:12251-12267. https://doi.org/10.18632/aging.103411
Dilberger B, Baumanns S, Spieth ST, Wenzel U, Eckert GP, . Infertility induced by auxin in PX627 Caenorhabditis elegans does not affect mitochondrial functions and aging parameters. . 12:12268-12284. https://doi.org/10.18632/aging.103413
Changbin Lei, Debora Colangelo, Prashanti Patil, Vivian Li, Kevin Ngo, Dong Wang, Qing Dong, Matthew J. Yousefzadeh, Hongsheng Lin, Joon Lee, James Kang, Gwendolyn Sowa, Tony Wyss-Coray, Laura J. Niedernhofer, Paul D. Robbins, Derek M. Huffman, Nam Vo,
Lei C, Colangelo D, Patil P, Li V, Ngo K, Wang D, Dong Q, Yousefzadeh MJ, Lin H, Lee J, Kang J, Sowa G, Wyss-Coray T, et al, . Influences of circulatory factors on intervertebral disc aging phenotype. . 12:12285-12304. https://doi.org/10.18632/aging.103421
Song B, Li X, Xu Q, Yin S, Wu S, Meng X, Huang C, Li J, . Inhibition of BMP3 increases the inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis. . 12:12305-12323. https://doi.org/10.18632/aging.103422
Rosalia Battaglia, Paolo Musumeci, Marco Ragusa, Davide Barbagallo, Marina Scalia, Massimo Zimbone, Josè Maria Lo Faro, Placido Borzì, Paolo Scollo, Michele Purrello, Elena Maria Vento, Cinzia Di Pietro,
Battaglia R, Musumeci P, Ragusa M, Barbagallo D, Scalia M, Zimbone M, Lo Faro JM, Borzì P, Scollo P, Purrello M, Vento EM, Di Pietro C, . Ovarian aging increases small extracellular vesicle CD81+ release in human follicular fluid and influences miRNA profiles. . 12:12324-12341. https://doi.org/10.18632/aging.103441
Raneem Habib, Ryong Kim, Heidemarie Neitzel, Ilja Demuth, Krystyna Chrzanowska, Eva Seemanova, Renaldo Faber, Martin Digweed, Reinhard Voss, Kathrin Jäger, Karl Sperling, Michael Walter,
Habib R, Kim R, Neitzel H, Demuth I, Chrzanowska K, Seemanova E, Faber R, Digweed M, Voss R, Jäger K, Sperling K, Walter M, . Telomere attrition and dysfunction: a potential trigger of the progeroid phenotype in nijmegen breakage syndrome. . 12:12342-12375. https://doi.org/10.18632/aging.103453
Milja Honkonen, Kati Vääräniemi, Outi Saijonmaa, Anna Nyman, Antti J. Tikkakoski, Jenni Koskela, Terho Lehtimäki, Mika Kähönen, Jukka Mustonen, Frej Fyhrquist, Ilkka Pörsti,
Honkonen M, Vääräniemi K, Saijonmaa O, Nyman A, Tikkakoski AJ, Koskela J, Lehtimäki T, Kähönen M, Mustonen J, Fyhrquist F, Pörsti I, . Leukocyte telomere length is inversely associated with arterial wave reflection in 566 normotensive and never-treated hypertensive subjects. . 12:12376-12392. https://doi.org/10.18632/aging.103459
Xu L, Mao Y, Chen G, . Risk factors for 2019 novel coronavirus disease (COVID-19) patients progressing to critical illness: a systematic review and meta-analysis. . 12:12410-12421. https://doi.org/10.18632/aging.103383
Wang J, Zhang W, Wu L, Mei Y, Cui S, Feng Z, Chen X, . New insights into the pathophysiological mechanisms underlying cardiorenal syndrome. . 12:12422-12431. https://doi.org/10.18632/aging.103354