Research Paper Volume 12, Issue 13 pp 13038—13058

Figure 1. Identification of circMET in NSCLC tissues and its prognostic significance. (A) Clustered heat map shows the expression profiles of circRNAs derived from the MET gene in four paired NSCLC and adjacent nontumor tissues by qRT-PCR. (B) Scheme illustrating the production of circMET. (C) and (D) circMET was differentially expressed in 94 paired NSCLC tissues and adjacent normal tissues using real-time PCR analysis. (E) and (F) In total, 94 NSCLC patients were individually divided into low- and high-expression groups according to the clinicopathological characteristics, including tumor size or lymph node metastasis. (G) Representative images of serial sections stained with H&E and IHC for MET expression in NSCLC tissues. (H) A positive correlation between circMET and MET was observed in NSCLC tissues. (I) and (J) Prognostic analysis of circMET expression in 94 NSCLC patients. GAPDH was used as an internal control. *P < 0.05, **P < 0.01, *** p < 0.001.