Research Paper Volume 12, Issue 13 pp 13038—13058
circMET promotes NSCLC cell proliferation, metastasis, and immune evasion by regulating the miR-145-5p/CXCL3 axis
Figure 5. CXCL3 exerts oncogenic effects in NSCLC tissues. (A) and (B) miR-145-5p and CXCL3 expression were detected in 94 paired NSCLC tissues and adjacent normal tissues using qRT-PCR. GAPDH was used as a control for loading. (C) A negative correlation between miR-145-5p and circMET was observed in NSCLC tissues. (D) A positive correlation between circMET and CXCL3 was observed in NSCLC tissues. (E) Representative images of TMA stained with H&E and IHC for CXCL3 expression in NSCLC tissues and adjacent nontumor tissues (−, absent; +, weak; ++, moderate; and +++, strong). Scale bar: 100um. The data are represented as the mean ± SD, * p < 0.05, ** p < 0.01, *** p < 0.001.