Figure 2. The study of salivary microbiota changes and periodontitis. (A) PCoA results of the salivary microbiota calculated by the severity of different periodontitis in all individuals, the p values were obtained by ADONIS (permutational MANOVA) analysis with Bray Curtis, Jaccard, unweighted and Weighted Unifracs. (B) The bacterial genera (Left) and species (Right) with significant changes in L, M, and H stage of periodontitis in healthy individuals were not included as the differential genera and species in the onset and treatment of diabetes, and the p value showed no significant difference when these differential genera and species were used to compare the naïve diabetic group with the other three groups.