Research Paper Volume 12, Issue 13 pp 13128—13146

Long-term low-dose ethanol intake improves healthspan and resists high-fat diet-induced obesity in mice


Figure 3. Altered gene expression pattern in LLE mice. (A) Principal component analysis (PCA) was performed on differentially expressed genes from the liver of 12-month old LLE mice. (n=6-8 for each group). (B) Volcano plot comparison of genes induced in LLE mice versus WT mice. (C) Gene ontology terms and KEGG pathway clustering of LLE mice. (D) Heatmap representation of genes involved in carbohydrate metabolism, lipid/fatty acid metabolism, NF-kappa B signaling, insulin signaling and AMPK signaling. (E) Protein-protein interaction network of differentially expressed genes of LLE mice.