Research Paper Volume 12, Issue 13 pp 13463—13476

Figure 1. BPV caused spinal cord oxidative injury to activate JNK signaling and elevate SOD2 transcription in rats. Con: intrathecal injection of 0.9% saline with 0.2 μl/g in rats; BPV: intrathecal injection of 2.5% BPV with 0.2 μl/g in rats. (A, B) spinal reflex function in different times (6^th h, 12^th h or 24^th h after intrathecal injection of 2.5% BPV or 0.9% saline with 0.2 μl/g) was investigated by PWT and TWL values; pre-drug: rats before intrathecal injection of 0.9% saline or 2.5% BPV; Values are the mean± SEM of n = 6; *: P< 0.05 compared with the pre-drug; #: P< 0.05 compared with group Con. (C–H) MDA and 8-OHdG production, JNK phosphorylation and SOD2 transcription were measured in spinal intumescentia lumbalis of rats in different times (6^th h, 12^th h or 24^th h after intrathecal injection of BPV or saline); Values are the mean± SEM of n = 6; *: P< 0.05 compared with the group Con.