Figure 1. The correlations among concentrations of serum metabolites (A) and the correlation matrix between the concentrations of metabolites and cardiovascular disease risk factors (B). A partial Spearman correlation analysis was used to calculate the correlation coefficients, adjusting for age and sex. The significance threshold was set at *p<0.05, **p<0.01, and ***p<0.001 after correcting for the false discovery rate. Abbreviations: BMI, body mass index; HDL–C, high–density lipoprotein cholesterol; GLU, serum glucose; HTDmed, use of antihypertensive medications; LDL–C, low–density lipoprotein cholesterol; SBP, systolic blood pressure.