Featured Nobel Articles

Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.
Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.
Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored a paper published in Aging.

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Volume 12, Issue 15

15 August, 2020
pp 15184—15874

About the Cover

The cover features Figure 2 "Levels of derived IgG1 Fc glycan traits across 27 different populations collected worldwide“ from Štambuk et al.

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Editorial

Rapamycin for aging stem cells

William S. Hambright, Marc J. Philippon, Johnny Huard,

https://doi.org/10.18632/aging.103816 pp 15184—15185

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Research Papers

COVID-19
COVID-19 mortality in Lombardy: the vulnerability of the oldest old and the resilience of male centenarians

Gabriella Marcon, Mauro Tettamanti, Giorgia Capacci, Giulia Fontanel, Marco Spanò, Alessandro Nobili, Gianluigi Forloni, Claudio Franceschi,

https://doi.org/10.18632/aging.103872 pp 15186—15195

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Inverse relationship between leukocyte telomere length attrition and blood mitochondrial DNA content loss over time

Anthony Y.Y. Hsieh, Elana Kimmel, Neora Pick, Laura Sauvé, Jason Brophy, Fatima Kakkar, Ari Bitnun, Melanie C.M. Murray, Hélène C.F. Côté,

https://doi.org/10.18632/aging.103703 pp 15196—15221

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Global variability of the human IgG glycome

Jerko Štambuk, Natali Nakić, Frano Vučković, Maja Pučić-Baković, Genadij Razdorov, Irena Trbojević-Akmačić, Mislav Novokmet, Toma Keser, Marija Vilaj, Tamara Štambuk, Ivan Gudelj, Mirna Šimurina, Manshu Song, Hao Wang, Marijana Peričić Salihović, Harry Campbell, Igor Rudan, Ivana Kolčić, Leigh Anne Eller, Paul McKeigue, Merlin L. Robb, Jonas Halfvarson, Metin Kurtoglu, Vito Annese, Tatjana Škarić-Jurić, Mariam Molokhia, Ozren Polašek, Caroline Hayward, Hannah Kibuuka, Kujtim Thaqi, Dragan Primorac, Christian Gieger, Sorachai Nitayaphan, Tim Spector, Youxin Wang, Therese Tillin, Nish Chaturvedi, James F. Wilson, Moses Schanfield, Maxim Filipenko, Wei Wang, Gordan Lauc,

https://doi.org/10.18632/aging.103884 pp 15222—15259

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The relationship between urinary Alzheimer-associated neuronal thread protein and blood biochemical indicators in the general population

Yuxia Li, Shaochen Guan, He Jin, Hongjun Liu, Meimei Kang, Xiaozhen Wang, Can Sheng, Yu Sun, Xuanyu Li, Xianghua Fang, Rong Wang,

https://doi.org/10.18632/aging.103356 pp 15260—15280

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Fish oil supplementation attenuates cognitive impairment by inhibiting neuroinflammation in STZ-induced diabetic rats

Gengyin Wang, Xiaohan Zhang, Xunyi Lu, Jiang Liu, Zhiyong Zhang, Zifeng Wei, Zeteng Wu, Jinhua Wang,

https://doi.org/10.18632/aging.103426 pp 15281—15289

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Neutrophil depletion enhances the therapeutic effect of PD-1 antibody on glioma

Peng-Fei Wang, Yu-Xiang Zhang, Jing Su, Kun Yao, Shou-Wei Li, Guang-Rui Huang, Chang-Xiang Yan,

https://doi.org/10.18632/aging.103428 pp 15290—15301

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Associations between serum metabolites and subclinical atherosclerosis in a Chinese population: the Taizhou Imaging Study

Yanfeng Jiang, Kexun Zhang, Zhen Zhu, Mei Cui, Yanpeng An, Yingzhe Wang, Chen Suo, Min Fan, Li Jin, Weizhong Tian, Xingdong Chen,

https://doi.org/10.18632/aging.103456 pp 15302—15313

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Anabolic-androgenic steroids and brain injury: miRNA evaluation in users compared to cocaine abusers and elderly people

Francesco Sessa, Monica Salerno, Luigi Cipolloni, Giuseppe Bertozzi, Giovanni Messina, Giulio Di Mizio, Alessio Asmundo, Cristoforo Pomara,

https://doi.org/10.18632/aging.103512 pp 15314—15327

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Interleukin-6 -174 G/C polymorphism is associated with the risk of basal cell carcinoma in a Chinese Han population

Jing Wang, Yi Chen,

https://doi.org/10.18632/aging.103518 pp 15328—15333

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Integrated nomograms to predict overall survival and recurrence-free survival in patients with combined hepatocellular cholangiocarcinoma (cHCC) after liver resection

Tao Wang, Xianwei Yang, Huairong Tang, Junjie Kong, Shu Shen, Haizhou Qiu, Wentao Wang,

https://doi.org/10.18632/aging.103577 pp 15334—15358

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Bioinformatics profiling integrating a four immune-related long non-coding RNAs signature as a prognostic model for papillary renal cell carcinoma

Yu Liu, Xin Gou, Zongjie Wei, Haitao Yu, Xiang Zhou, Xinyuan Li,

https://doi.org/10.18632/aging.103580 pp 15359—15373

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Stearoyl-CoA desaturase 1 (SCD1) facilitates the growth and anti-ferroptosis of gastric cancer cells and predicts poor prognosis of gastric cancer

Chao Wang, Min Shi, Jun Ji, Qu Cai, Qianfu Zhao, Jinling Jiang, Jing liu, Huan Zhang, Zhenggang Zhu, Jun Zhang,

https://doi.org/10.18632/aging.103598 pp 15374—15391

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PDIA3 correlates with clinical malignant features and immune signature in human gliomas

Hao Zhang, Yulai Zhou, Quan Cheng, Ziyu Dai, Zeyu Wang, Fangkun Liu, Fan Fan, Biqi Cui, Hui Cao,

https://doi.org/10.18632/aging.103601 pp 15392—15413

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Depletion of exosomal circLDLR in follicle fluid derepresses miR-1294 function and inhibits estradiol production via CYP19A1 in polycystic ovary syndrome

Xin Huang, Bi Wu, Miaoxin Chen, Ling Hong, Pengcheng Kong, Zhiyun Wei, Xiaoming Teng,

https://doi.org/10.18632/aging.103602 pp 15414—15435

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MicroRNA-21-3p accelerates diabetic wound healing in mice by downregulating SPRY1

Yaohong Wu, Kun Zhang, Rong Liu, Hexing Zhang, Dong Chen, Shuangqi Yu, Wei Chen, Song Wan, Yi Zhang, Zhiwei Jia, Rongchun Chen, Fan Ding,

https://doi.org/10.18632/aging.103610 pp 15436—15445

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The spleen mediates chronic sleep restriction-mediated enhancement of LPS-induced neuroinflammation, cognitive deficits, and anxiety-like behavior

Dan Xu, Yujing Zhang, Bing Xie, Hua Yao, Yin Yuan, Shiying Yuan, Jiancheng Zhang,

https://doi.org/10.18632/aging.103659 pp 15446—15461

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Interaction effects of significant risk factors on overweight or obesity among 7222 preschool–aged children from Beijing

Bo Zhou, Yuan Yuan, Kundi Wang, Wenquan Niu, Zhixin Zhang,

https://doi.org/10.18632/aging.103701 pp 15462—15477

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The impact of folate and vitamin B12 status on cognitive function and brain atrophy in healthy elderly and demented Austrians, a retrospective cohort study

Jasmin Rabensteiner, Edith Hofer, Günter Fauler, Eva Fritz-Petrin, Thomas Benke, Peter Dal-Bianco, Gerhard Ransmayr, Reinhold Schmidt, Markus Herrmann,

https://doi.org/10.18632/aging.103714 pp 15478—15491

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Gene expression-based clinical predictions in lung adenocarcinoma

Yanlu Xiong, Jie Lei, Jinbo Zhao, Yangbo Feng, Tianyun Qiao, Yongsheng Zhou, Tao Jiang, Yong Han,

https://doi.org/10.18632/aging.103721 pp 15492—15503

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Human T-cell lymphotropic virus type-1 infection associated with sarcopenia: community-based cross-sectional study in Goto, Japan

Hirotomo Yamanashi, Kenichi Nobusue, Fumiaki Nonaka, Yukiko Honda, Yuji Shimizu, Shin-Ya Kawashiri, Mai Izumida, Yoshinao Kubo, Mami Tamai, Yasuhiro Nagata, Katsunori Yanagihara, Bharati Kulkarni, Sanjay Kinra, Atsushi Kawakami, Takahiro Maeda,

https://doi.org/10.18632/aging.103736 pp 15504—15513

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Ubiquinol supplementation in elderly patients undergoing aortic valve replacement: biochemical and clinical aspects

Patrick Orlando, Jacopo Sabbatinelli, Sonia Silvestri, Fabio Marcheggiani, Ilenia Cirilli, Phiwayinkosi Vusi Dludla, Alberto Molardi, Francesco Nicolini, Luca Tiano,

https://doi.org/10.18632/aging.103742 pp 15514—15531

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circIQCH sponges miR-145 to promote breast cancer progression by upregulating DNMT3A expression

Yuehua Li, Baohong Jiang, Zhengxi He, Hongbo Zhu, Rongfang He, Shanji Fan, Xiaoping Wu, Liming Xie, Xiusheng He,

https://doi.org/10.18632/aging.103746 pp 15532—15545

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Glycochenodeoxycholic acid induces stemness and chemoresistance via the STAT3 signaling pathway in hepatocellular carcinoma cells

Changying Shi, Jiamei Yang, Longmiao Hu, Boyi Liao, Liang Qiao, Weifeng Shen, Feng Xie, Guoqing Zhu,

https://doi.org/10.18632/aging.103751 pp 15546—15555

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Evaluation of chromosomal abnormalities and copy number variations in late trimester pregnancy using cordocentesis

Meiying Cai, Na Lin, Yuan Lin, Hailong Huang, Liangpu Xu,

https://doi.org/10.18632/aging.103575 pp 15556—15565

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The association between KLF4 as a tumor suppressor and the prognosis of hepatocellular carcinoma after curative resection

Min Xue, Chenhao Zhou, Yan Zheng, Ziping Zhang, Shun Wang, Yan Fu, Manar Atyah, Xiaolong Xue, Le Zhu, Qiongzhu Dong, Huliang Jia, Ning Ren, Ruolei Hu,

https://doi.org/10.18632/aging.103592 pp 15566—15580

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hsa_circRNA6448-14 promotes carcinogenesis in esophageal squamous cell carcinoma

Yaowen Zhang, Xiang Yuan, Ning Yue, Lidong Wang, Junqi Liu, Ningtao Dai, Haijun Yang, Ruitai Fan, Fuyou Zhou,

https://doi.org/10.18632/aging.103650 pp 15581—15602

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Transcriptome analysis of mouse aortae reveals multiple novel pathways regulated by aging

Ping Gao, Pan Gao, Mihyun Choi, Kavya Chegireddy, Orazio J. Slivano, Jinjing Zhao, Wei Zhang, Xiaochun Long,

https://doi.org/10.18632/aging.103652 pp 15603—15623

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An autophagy-related long non-coding RNA prognostic signature accurately predicts survival outcomes in bladder urothelial carcinoma patients

Zhuolun Sun, Changying Jing, Chutian Xiao, Tengcheng Li,

https://doi.org/10.18632/aging.103718 pp 15624—15637

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Protection of procyanidin B2 on mitochondrial dynamics in sepsis associated acute kidney injury via promoting Nrf2 nuclear translocation

Jian-Xing Liu, Chen Yang, Ze-Jian Liu, Hong-Yong Su, Wei-Huang Zhang, Qingjun Pan, Hua-Feng Liu,

https://doi.org/10.18632/aging.103726 pp 15638—15655

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CTLA-4 immunotherapy exposes differences in immune response along with different tumor progression in colorectal cancer

Xiaocong Fu, Hua Luo, Yuhui Zheng, Shengpeng Wang, Zhangfeng Zhong, Yitao Wang, Yeguo Yang,

https://doi.org/10.18632/aging.103765 pp 15656—15669

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COVID-19
Elevated Lactate Dehydrogenase (LDH) level as an independent risk factor for the severity and mortality of COVID-19

Chang Li, Jianfang Ye, Qijian Chen, Weihua Hu, Lingling Wang, Yameng Fan, Zhanjin Lu, Jie Chen, Zaishu Chen, Shiyan Chen, Junlu Tong, Wei Xiao, Jin Mei, Hongyun Lu,

https://doi.org/10.18632/aging.103770 pp 15670—15681

View Abstract PDF Full-Text How to Cite Special Collection on COVID-19 Part 2

Vascular, inflammatory and metabolic risk factors in relation to dementia in Parkinson’s disease patients with type 2 diabetes mellitus

Ting Wang, Feilan Yuan, Zhenze Chen, Shuzhen Zhu, Zihan Chang, Wanlin Yang, Bin Deng, Rongfang Que, Peihua Cao, Yinxia Chao, Lingling Chan, Ying Pan, Yanping Wang, Linting Xu, Qiurong Lyu, Piu Chan, Midori A. Yenari, Eng-King Tan, Qing Wang,

https://doi.org/10.18632/aging.103776 pp 15682—15704

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Gene expression profiles during postnatal development of the liver and pancreas in giant pandas

Jinnan Ma, Fujun Shen, Lei Chen, Honglin Wu, Yan Huang, Zhenxin Fan, Rong Hou, Bisong Yue, Xiuyue Zhang,

https://doi.org/10.18632/aging.103783 pp 15705—15729

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COVID-19
Risk factors for severe cases of COVID-19: a retrospective cohort study

Feng He, Qingqing Luo, Ming Lei, Lixin Fan, Xinning Shao, Guanglie Huang, Jun Zeng, Ziwen Zhao, Shuguang Qin, Zhi Yang, Na Yu, Liuping Yang, Jie Cao,

https://doi.org/10.18632/aging.103803 pp 15730—15740

View Abstract PDF Full-Text How to Cite Special Collection on COVID-19 Part 2

Radioprotectors.org: an open database of known and predicted radioprotectors

Alexander M. Aliper, Marine E. Bozdaganyan, Viktoria A. Sarkisova, Alexander P. Veviorsky, Ivan V. Ozerov, Philipp S. Orekhov, Mikhail B. Korzinkin, Alexey Moskalev, Alex Zhavoronkov, Andreyan N. Osipov,

https://doi.org/10.18632/aging.103815 pp 15741—15755

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MiR-483 induces senescence of human adipose-derived mesenchymal stem cells through IGF1 inhibition

Junyan Shen, Xiaoqi Zhu, Hailiang Liu,

https://doi.org/10.18632/aging.103818 pp 15756—15770

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COVID-19
The effect of emergency surgery on acute abdomen patients with COVID-19 pneumonia: a retrospective observational study

Ning Zhao, Liang Wu, Yifeng Cheng, Hai Zheng, Ping Hu, Chaojie Hu, Ding Chen, Peng Xu, Qingyong Chen, Ping Cheng, Jinhuang Chen, Gang Zhao,

https://doi.org/10.18632/aging.103839 pp 15771—15783

View Abstract PDF Full-Text How to Cite Special Collection on COVID-19 Part 2

COVID-19
Revealing the targets and mechanisms of vitamin A in the treatment of COVID-19

Rong Li, Ka Wu, Yu Li, Xiao Liang, William Ka Fai Tse, Lu Yang, Keng Po Lai,

https://doi.org/10.18632/aging.103888 pp 15784—15796

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Reviews

Perioperative neurocognitive dysfunction: thinking from the gut?

Xiaolin Xu, Yimin Hu, Enshi Yan, Gaofeng Zhan, Cunming Liu, Chun Yang,

https://doi.org/10.18632/aging.103738 pp 15797—15817

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The role of Anaphase Promoting Complex activation, inhibition and substrates in cancer development and progression

Cordell VanGenderen, Troy Anthony Alan Harkness, Terra Gayle Arnason,

https://doi.org/10.18632/aging.103792 pp 15818—15855

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Pompe disease: pathogenesis, molecular genetics and diagnosis

Simona Taverna, Giuseppe Cammarata, Paolo Colomba, Serafina Sciarrino, Carmela Zizzo, Daniele Francofonte, Marco Zora, Simone Scalia, Chiara Brando, Alessia Lo Curto, Emanuela Maria Marsana, Roberta Olivieri, Silvia Vitale, Giovanni Duro,

https://doi.org/10.18632/aging.103794 pp 15856—15874

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Featured Nobel Articles

Volume 12, Issue 15

About the Cover

Editorial

William S. Hambright, Marc J. Philippon, Johnny Huard,

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Research Papers

COVID-19 COVID-19 mortality in Lombardy: the vulnerability of the oldest old and the resilience of male centenarians

Gabriella Marcon, Mauro Tettamanti, Giorgia Capacci, Giulia Fontanel, Marco Spanò, Alessandro Nobili, Gianluigi Forloni, Claudio Franceschi,

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Anthony Y.Y. Hsieh, Elana Kimmel, Neora Pick, Laura Sauvé, Jason Brophy, Fatima Kakkar, Ari Bitnun, Melanie C.M. Murray, Hélène C.F. Côté,

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Yuxia Li, Shaochen Guan, He Jin, Hongjun Liu, Meimei Kang, Xiaozhen Wang, Can Sheng, Yu Sun, Xuanyu Li, Xianghua Fang, Rong Wang,

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Gengyin Wang, Xiaohan Zhang, Xunyi Lu, Jiang Liu, Zhiyong Zhang, Zifeng Wei, Zeteng Wu, Jinhua Wang,

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Peng-Fei Wang, Yu-Xiang Zhang, Jing Su, Kun Yao, Shou-Wei Li, Guang-Rui Huang, Chang-Xiang Yan,

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Yanfeng Jiang, Kexun Zhang, Zhen Zhu, Mei Cui, Yanpeng An, Yingzhe Wang, Chen Suo, Min Fan, Li Jin, Weizhong Tian, Xingdong Chen,

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Francesco Sessa, Monica Salerno, Luigi Cipolloni, Giuseppe Bertozzi, Giovanni Messina, Giulio Di Mizio, Alessio Asmundo, Cristoforo Pomara,

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Jing Wang, Yi Chen,

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Tao Wang, Xianwei Yang, Huairong Tang, Junjie Kong, Shu Shen, Haizhou Qiu, Wentao Wang,

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Yu Liu, Xin Gou, Zongjie Wei, Haitao Yu, Xiang Zhou, Xinyuan Li,

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Chao Wang, Min Shi, Jun Ji, Qu Cai, Qianfu Zhao, Jinling Jiang, Jing liu, Huan Zhang, Zhenggang Zhu, Jun Zhang,

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Hao Zhang, Yulai Zhou, Quan Cheng, Ziyu Dai, Zeyu Wang, Fangkun Liu, Fan Fan, Biqi Cui, Hui Cao,

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Xin Huang, Bi Wu, Miaoxin Chen, Ling Hong, Pengcheng Kong, Zhiyun Wei, Xiaoming Teng,

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Yaohong Wu, Kun Zhang, Rong Liu, Hexing Zhang, Dong Chen, Shuangqi Yu, Wei Chen, Song Wan, Yi Zhang, Zhiwei Jia, Rongchun Chen, Fan Ding,

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Dan Xu, Yujing Zhang, Bing Xie, Hua Yao, Yin Yuan, Shiying Yuan, Jiancheng Zhang,

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Bo Zhou, Yuan Yuan, Kundi Wang, Wenquan Niu, Zhixin Zhang,

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Jasmin Rabensteiner, Edith Hofer, Günter Fauler, Eva Fritz-Petrin, Thomas Benke, Peter Dal-Bianco, Gerhard Ransmayr, Reinhold Schmidt, Markus Herrmann,

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COVID-19
COVID-19 mortality in Lombardy: the vulnerability of the oldest old and the resilience of male centenarians