Research Paper Volume 12, Issue 18 pp 17930—17947
Modulating redox homeostasis and cellular reprogramming through inhibited methylenetetrahydrofolate dehydrogenase 2 enzymatic activities in lung cancer
Figure 4. MTHFD2 knockdown and in vivo tumor formation ability. The cancer initiating ability (A), and tumor volumes (B) after subcutaneous injection of different cell number of respective vector control and MTHFD2-knockdown cell lines of A549, H1299 and H441 into the right flank of 6-week-old NOD/SCID mice (n = 5). *** indicate p<0.001 using one-way ANOVA, compared to vector control group.