Research Paper Volume 12, Issue 18 pp 17930—17947
Modulating redox homeostasis and cellular reprogramming through inhibited methylenetetrahydrofolate dehydrogenase 2 enzymatic activities in lung cancer
Figure 6. MTHFD2 and maintenance of redox homeostasis under low oxygen tension. Rate of change (%) of (A) NADPH and (B) ROS production in vector control and MTHFD2-knockdown groups of A549, H1299 and H441 cells after their treatment with 200 μM of CoCl2 for 24 hours. *, ** and *** indicate p<0.05, p<0.01 and p<0.001, respectively using paired t-test, compared to shVector group.