Research Paper Volume 12, Issue 16 pp 16099—16110
IL-21 mediates microRNA-423-5p /claudin-5 signal pathway and intestinal barrier function in inflammatory bowel disease
Figure 4. MiR-423-5p regulates the intestinal epithelial barrier function by targeting claudin-5. (A) The effect of miR-423-5p on intestinal epithelial barrier function. n=3. (B) RT-PCR was employed to detect the mRNA level of claudin-1, claudin-4, claudin-5, claudin-8, claudin-11, occludin, and ZO-1. n=6. (C) The effect of miR-423-5p and claudin-5 on TEER in Caco-2 cells. n=4. (D) The FD4 level was detected after claudin-5/vector transfection with miR-423-5p mimic/miR-NC. n=5. *P < 0.05, **P < 0.01.