Research Paper Volume 12, Issue 17 pp 16852—16866
Spermidine inhibits neurodegeneration and delays aging via the PINK1-PDR1-dependent mitophagy pathway in C. elegans
Figure 1. Effect of spermidine on wrn-1(gk99) worms. (A) Effect of different concentrations of spermidine treatment on survival curves of wrn-1(gk99) worms, n=83-102. (B) Effect of 5mM spermidine treatment on lipofuscin deposition level of wrn-1(gk99) worms, n=12-15. (C). Effect of 5mM spermidine treatment on locomotor capacity of N2 and wrn-1(gk99) worms, n=20. (D) Effect of 5mM spermidine treatment on autophagy-related genes bec-1 and sqst-1 of wrn-1(gk99) worms, n=3. Data are represented as mean± SD, *P < 0.05, **P < 0.01 vs control.