Research Paper Volume 12, Issue 16 pp 16142—16154

Figure 5. LAIR-1 inhibits ovarian cancer cell growth in vivo. Nude BALB/c mice were subcutaneously injected with control (NC) and LAIR-1 overexpression SKOV3 cells (OE). (A) The tumor tissues obtained from mice were imaged using a digital camera (B). Tumor volume in each mouse was monitored every two days. Data are presented as mean ± SE (n = 6). (C) The tumors tissues were weighed by analytical balance. Data are presented as mean ± SE (n = 6). (D) Western blot analyses of LAIR-1 expression in tumor tissues derived from control and LAIR-1 overexpression SKOV3 cells. GAPDH was used as a loading control. (E) Western blot analyses of p-AKT, AKT, p-mTOR, mTOR pathways in tumor tissues derived from control and LAIR-1 overexpression SKOV3 cells. GAPDH was used as a loading control.