Research Paper Volume 12, Issue 17 pp 16899—16920
Umbilical cord mesenchymal stem cells protect thymus structure and function in aged C57 mice by downregulating aging-related genes and upregulating autophagy- and anti-oxidative stress-related genes
Figure 15. Changes in p16 expression in the mouse thymus after treatment with mUCMSCs. Note: (A, B) show P16 immunohistochemical staining of thymus tissue in the treatment group after treatment for 1 month. The expression of p16 protein in the thymus of the treatment group was increased. (C, D) show P16 immunohistochemical staining of mouse thymus tissue in the model control group. (E, F) show immunohistochemical staining of thymus P16 in young control mice. (G) shows the difference in P16 expression in mouse thymus tissue between different groups after mUCMSC treatment. All dark brown tissue sections were strongly positive, brownish-yellow staining was moderately positive, light yellow staining was weakly positive, and blue nuclei were negative. Note *** indicates p < 0.001, ** indicates p < 0.01, * indicates p < 0.05, and NS indicates p > 0.05.