Research Paper Volume 12, Issue 17 pp 16899—16920
Umbilical cord mesenchymal stem cells protect thymus structure and function in aged C57 mice by downregulating aging-related genes and upregulating autophagy- and anti-oxidative stress-related genes
Figure 17. Sirt1 expression level in the mouse thymus after treatment with mUCMSCs. Note: (A, B) show immunohistochemical staining of Sirt1 in the thymus tissue after 1 month of treatment in the treatment group. The levels of Sirt1 were increased to different degrees in the treatment group. (C, D) show Sirt1 immunohistochemical staining of the mouse thymus tissue in the model control group. (E, F) show immunohistochemical staining of thymus Sirt1 in young control mice. (G) shows the difference in Sirt1 expression in mouse thymus tissue between different groups after mUCMSC treatment. All dark brown tissue sections were strongly positive, brownish-yellow staining was moderately positive, pale yellow staining was weakly positive, and blue nuclei were negative. *** indicates p < 0.001, ** indicates p < 0.01, * indicates p < 0.05, and NS indicates p > 0.05.