Research Paper Volume 12, Issue 17 pp 16899—16920
Umbilical cord mesenchymal stem cells protect thymus structure and function in aged C57 mice by downregulating aging-related genes and upregulating autophagy- and anti-oxidative stress-related genes
Figure 21. Expression of P62 in the thymus tissue of mice after mUCMSC treatment. Note: (A, B) show immunohistochemical staining of thymus P62 in young control mice. (C, D) show immunohistochemical staining of P62 in the thymus tissue after treatment for 1 month in the treatment group. (E, F) show immunohistochemical staining of P62 in the thymus tissue of model control mice. (G) shows the difference in P62 expression in mouse thymus tissue between different groups after mUCMSC treatment. All dark brown tissue sections were strongly positive, brownish-yellow staining was moderately positive, light yellow staining was weakly positive, and blue nuclei were negative. *** indicates p < 0.001, ** indicates p < 0.01, * indicates p < 0.05, and NS indicates p > 0.05. The P62 activity in the model control group was the lowest, and the P62 activity in the treatment group was the highest.