Research Paper Volume 12, Issue 16 pp 16155—16171
RPP30, a transcriptional regulator, is a potential pathogenic factor in glioblastoma
Figure 1. Age-related genes are mainly enriched in transcriptional regulation. (A, B) The correlation between gene expression and age of primary GBM in CGGA and TCGA databases. (C) The correlation between gene expression and age of non-tumor brain samples in GSE53890. The statistical significance between age and gene expression was assessed by Pearson correlation analysis. (D, E) Functional enrichment of age-related genes of primary GBM in CGGA and TCGA databases. (F) Functional enrichment of age-related genes of non-tumor brain samples in GSE53890. (G) Multivariable COX analysis of Age-related genes in primary GBM. Among the above genes, only RPP30 was an independent prognostic factor by multivariate COX analysis. Multivariate COX analysis of age-related genes was performed separately.