Research Paper Volume 12, Issue 15 pp 15374—15391

Figure 1. Expression level and prognostic value of SCD1 in various types of cancer. (A) SCD1 mRNA expression level in pan-cancer tissues and normal tissues. BLCA, bladder urothelial carcinoma; BRCA, breast invasive carcinoma; CESC, cervical squamous cell carcinoma and endocervical adenocarcinoma; CHOL, cholangio carcinoma; COAD, colon adenocarcinoma; ESCA, esophageal carcinoma; GBM, glioblastoma multiforme; HNSC, head and neck squamous cell carcinoma; KICH, kidney chromophobe; KIRC, kidney renal clear cell carcinoma; KIRP, kidney renal papillary cell carcinoma; LIHC, liver hepatocellular carcinoma; LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma; PAAD, pancreatic adenocarcinoma; PRAD, prostate adenocarcinoma; PCPG, pheochromocytoma and paraganglioma; READ, rectum adenocarcinoma; SARC, sarcoma; SKCM, skin cutaneous melanoma; THCA, thyroid carcinoma; THYM, thymoma; STAD, stomach adenocarcinoma; UCEC, uterine corpus endometrial carcinoma; (B) SCD1 mRNA expression were significantly overexpressed in gastric cancer tissues compared with peritumor tissues in TCGA database. (C, D) SCD1 mRNA expression were significantly overexpressed in gastric cancer tissues compared with normal ones in GSE13911 and GSE19826 database. (E) The mRNA expression level of SCD1 in different lymph node metastasis based on TCGA-STAD database. (F) The mRNA expression level of SCD1 in different AJCC stages based on TCGA-STAD database. (G) Overall survival of patients in SCD1-low expression group and SCD1-high expression group based on GEO database. (H) Post-progression survival of patients in SCD1-low expression group and SCD1-high expression group based on GEO database. (I) Progression-free survival of patients in SCD1-low expression group and SCD1-high expression group based on GEO database. The survival time of patients was compared between groups using the Mantel-Cox test. *, P <0.05; **, P <0.01; ***, P <0.001; ****, P <0.0001, respectively. (J) Overall survival of patients in SCD1-low expression group and SCD1-high expression group based on TCGA-STAD database. (K) Gastric cancer nomogram of overall survival for patients in TCGA-STAD database was examined by adding up of the points identified on the points scale for each characteristics. The total points existed on the bottom scales stand for the probability of 1-, 3- and 5- year survival. (L) Time-dependent area under the curve (AUC).