Research Paper Volume 12, Issue 15 pp 15392—15413

Figure 1. The relationship between PDIA3 expression and various characteristics. (A) PDIA3 expression in different WHO grades from TCGA and CGGA. (B) PDIA3 was upregulated in 1p/19q non-codeletion cases. (C) PDIA3 expression in different IDH state from TCGA and CGGA dataset. (D) ROC curve analysis showed that PDIA3 had 84.0% and 71.5% sensitivity and specificity to predict IDH wild-type state gliomas in TCGA and CGGA, respectively. (E) The PDIA3 expression pattern in pan-gliomas based on TCGA molecular subtypes. ROC curves showed PDIA3 as a predictor of more aggressive subtype gliomas. (F) The PDIA3 expression pattern in GBM from the TCGA molecular subtype. ROC curve analysis showed that PDIA3 had 80.4% sensitivity and specificity to predict more aggressive subtype gliomas. (G) PDIA3 has higher expression in GBM than in LGG at the protein level. *P < .05, **P < .01, ***P < .001.