Research Paper Volume 12, Issue 17 pp 16759—16774
HDAC4 inhibition disrupts TET2 function in high-risk MDS and AML
Figure 5. TET2 and HDAC4 expression is positively correlated in high-risk MDS/AML. (A, B) Microarray expression data from total BM of MDS (A, n = 206) or mononuclear AML (B, n = 96) cells. P value was calculated by Pearson r correlation. (C) HDAC4 expression data from total BM from healthy donors (n = 73) or normal karyotype AML patients (n = 351). P value was calculated by unpaired t test. (D) Overall survival in 163 normal karyotype AML patients based on clustering of HDAC4 expression. Patients were separated into 3 expression groups—low (n = 61), middle (n = 69) and high (n = 33)—based on a standard K-means clustering approach. Kaplan-Meier curves were generated and log-rank p-values calculated to assess statistical significance.