Research Paper Volume 12, Issue 18 pp 18084—18098

RAI14 silencing suppresses progression of esophageal cancer via the STAT3 pathway

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Figure 7. RAI14 knockdown prevents tumor growth of EC in vivo. Nude mice were injected with TE-1 cells that were transfected with siNC (Nos. 1–6) or siRAI14-2 (Nos. 7–12). (A) Tumor volume in mice. (B) Growth curve of tumor volume (mm3). (C) HE staining of tumor samples. (D) The protein expression of RAI14 was determined by Western blotting. (E) Immunohistochemical results of RAI14 and Ki67 expression in tumor tissue samples. (F) The immunohistochemical assay score in each group. *P < 0.05 versus respective control group (siNC).