Research Paper Volume 12, Issue 18 pp 18127—18136
GHR knockdown enhances the sensitivity of HCC cells to sorafenib
Figure 5. GHR knockdown enhanced sorafenib inhibiting of cell migration. (A) Wound healing assay measured cell migration of HCC cells siGHR or/and sorafenib; (B) the width ratio was calculated by the wound width/the distance measured at 0 h. All data shown represented the mean ± SEM. ***p<0.001; (C) The results of western blotting assay showed that GHR knockdown and sorafenib combination suppressed the protein levels of MMP2 and MMP9 and promoted the expression of E-cadherin in HepG2 and Huh7 cells.