Research Paper Volume 12, Issue 17 pp 17079—17098
High expression of UNC5B enhances tumor proliferation, increases metastasis, and worsens prognosis in breast cancer
Figure 6. Enrichment analysis of UNC5B and its neighboring altered genes in breast cancer. The functions of UNC5B and the 20 most frequently altered UNC5B-neighboring genes were predicted in Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses using the “clusterProfiler” package in R. (A) Cellular components. (B) Biological processes. (C) Molecular functions. (D) KEGG pathway enrichment analysis. (E) Detailed annotation of the Ras signaling pathway regulated by UNC5B-associated gene alterations. Nodes marked in red represent altered genes.