Research Paper Volume 12, Issue 17 pp 17150—17166

Figure 2. LNK resulted in worse diet-induced obesity, impaired glucose tolerance and increased insulin resistance under HFD feeding for 16 weeks. Body weights (A) were measured in 6 to 8-week-old LNK^-/- (n=13) or WT mice (n=13). (B–E) Food intake and body weight after HFD or NCD feeding for 16 weeks were shown. Abdominal pathologic specimen (F) and MRI analyses (G) were shown to compare abdominal fat volume. GTTs (H and J) and ITTs (I and K) in WT (filled symbols) or LNK^-/- mice (open symbols) were measured. Blood glucose concentrations were measured at the indicated times. Fasting insulin concentration (L) were measured in mice after NCD or HFD feeding for 16 weeks. HFD: LNK^-/- n=7, WT n=6; NCD: LNK^-/- n=6, WT n=7. Data were shown as mean ± SD. Statistical analysis was performed by Student’s t-test. *p < 0.05, **p < 0.01, ***p < 0.001.