Dynamic changes in vascular size and density in transgenic mice with Alzheimer’s disease

Xiaowen Xu; Tong Meng; Qingqing Wen; Mengling Tao; Peijun Wang; Kai Zhong; Yong Shen

doi:doi:10.18632/aging.103672

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Research Paper Volume 12, Issue 17 pp 17224—17234

Dynamic changes in vascular size and density in transgenic mice with Alzheimer’s disease

Figure 1. Analysis of microvascular density (Density), mean vessel diameter in the voxel (mVD), and vessel size index (VSI). (A) The first step of data processing. Two regions of interest (ROIs) were delineated on T₂WI and projected to other images. The ROI delineated by the blue line is cortical region, and the ROI delineated by the green line is hippocampal region. (B) The second step of data processing. Maps of mask, ΔR₂ and ΔR2* obtained from intermediate steps of data processing. (C) The third step of data processing. Colormaps of Density, mVD and VSI of obtained images.