Research Paper Volume 12, Issue 17 pp 17235—17256
Mitophagy impairment is involved in sevoflurane-induced cognitive dysfunction in aged rats
Figure 4. Sevoflurane induced mitophagy dysfunction in vivo. Eighteen-month-old rats were subjected to 2% sevoflurane for 5 h (SEV). The LC3B, p62 and Tomm20 protein levels in the hippocampus were determined by western blotting analysis (A). The results of semi-quantitative analysis of LC3B, p62, Tomm20 and β-actin are shown in (B). Cathepsin B (CTS B) and β-actin levels were determined by western blot (C). Results of semi-quantitative analysis of Cathepsin B bands are shown in (D). The data are expressed as mean ± SD. *P<0.05, **P<0.01 Ctrl vs SEV.