Research Paper Volume 12, Issue 17 pp 17271—17287

Figure 3. Comparative analysis of differentially expressed circRNAs in ARC and diabetic cataract (DC) samples. (A) A volcano plot of differential circRNAs in ARC. The vertical lines represent two-fold (log2 scaled) increased and decreased expression. The horizontal line shows P = 0.05 (-log10 scaled). Blue and red dots indicate circRNAs with statistically significant differential expression. (B) A Venn diagram shows differentially expressed circRNAs in ARC and DC samples. (C) Chromosomal distribution of expressed circRNAs. The outermost layer displays the location of the circRNAs in the human chromosomes. The inner circles from the outside to the inside show the expression distribution of all circRNAs in ARC and normal samples, differentially expressed circRNAs in ARC, and differentially expressed circRNAs in DC in turn. (D) Correlation of up- and down-regulated circRNAs in differential fold changes between ARC and DC samples (compared with normal tissues), and Pearson’s correlation coefficient R is presented.