Research Paper Volume 12, Issue 17 pp 17271—17287

Profiling of circular RNAs in age-related cataract reveals circZNF292 as an antioxidant by sponging miR-23b-3p

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Figure 6. General characteristics of circZNF292. (A) RNA-Seq results of circZNF292 in the plasma from ARC patients. LogCPM by edgeR is the CPM value normalized by edgeR software and scaled by log2 (***, P<0.001). (B) The negative correlation of relative expression between circZNF292 and miR-23b-3p detected by qPCR (Pearson’s correlation coefficient R is presented and P < 0.05). (C) CircZNF292 was located between the second and fourth exons of its host gene. (D) Dual-luciferase reporter assay between circZNF292 and miR-23b-3p.