Research Paper Volume 12, Issue 15 pp 15624—15637

Figure 1. Construction and validation of the autophagy-related lncRNA prognostic signature in BCLA patients. (A) The univariate Cox regression analysis results show that 7 autophagy-related lncRNAs, AC002553.2, Z83843.1, LINC02178, FAM13A−AS1, USP30−AS1, AC108449.2 and AC243960.1, correlate with overall survival (OS) of BCLA patients from the TCGA database. (B) Kaplan–Meier survival curve analysis shows that survival time of patients with high-risk scores based on the autophagy-related lncRNA prognostic signature is significantly shorter than those with low-risk scores. (C) Principal components analysis (PCA) based on the confirmed five autophagy-related lncRNAs showed two significantly different distribution patterns between high-risk and low-risk groups. (D) Receiver operating characteristic (ROC) curve analysis shows the accuracy of the autophagy-related lncRNA prognostic signature in predicting survival times (prognosis) of BCLA patients from the TCGA database. (E) Distribution of risk scores of high- and low-risk BCLA patients based on the autophagy-related lncRNA prognostic signature. (F) Scatter plot shows the correlation between survival time and risk score of BCLA patients based on the autophagy-related lncRNA prognostic signature. (G) Heatmap shows that high-risk patients expressed higher levels of risk factors (AC108449.2 and LINC02178), while low-risk patients expressed higher levels of protective factors (Z83843.1, FAM13A−AS1 and USP30−AS1).