Research Paper Volume 12, Issue 15 pp 15624—15637

Figure 6. Construction of the autophagy-related lncRNA–mRNA co-expression network and functional enrichment analyses. (A) Diagrammatic representation of the autophagy-related lncRNA–mRNA network shows 77 lncRNA-mRNA co-expression pairs formed between 5 autophagy-related lncRNAs and 49 mRNAs. The yellow circles correspond to autophagy-related lncRNAs, and the gray diamonds correspond to the mRNAs. Every edge represents a co-expression relationship between an lncRNA and an mRNA in the context of BCLA. (B) The Sankey diagram shows the connection degree between the 49 mRNAs and 5 autophagy-related lncRNAs (risk/protective). (C–E) Gene Ontology (GO) analysis results show the enriched (C) biological processes, (D) cell components and (E) molecular functions associated with the mRNAs that co-express with the 5 autophagy-related lncRNAs. (F) Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis results shows the enriched signaling pathways associated with the mRNAs that co-express with the 5 autophagy-related lncRNAs.