Figure 3. Higher concentrations of blood biomarkers in HPG axis and the risk of dementia or cognitive decline. *One of the studies did not report case and sample size. Abbreviations: bio, bioavailable; DHT, dihydrotestosterone; E2, estradiol; FSH, follicle-stimulating hormone; LH, luteinizing hormone; SHBG, sex hormone-binding globulin; T, testosterone.