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The cover features Figure 1 "Metformin blunts the global transcriptomic changes induced by PRT in human skeletal muscle“ from Kulkarni et al.

Volume 12, Issue 20

31 October, 2020
pp 19828—20930

About the Cover

The cover features Figure 1 "Metformin blunts the global transcriptomic changes induced by PRT in human skeletal muscle“ from Kulkarni et al.


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Editorials

Liver cholesterol matters

Bishuang Cai, Xiaobo Wang,
https://doi.org/10.18632/aging.104208 pp 19828—19829
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ROS, Klotho and mTOR in cardiorenal aging

Nastaran Daneshgar, Dao-Fu Dai,
https://doi.org/10.18632/aging.104209 pp 19830—19831
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MerTK, a risk factor for NASH fibrosis

Xiaobo Wang, Bishuang Cai,
https://doi.org/10.18632/aging.104210 pp 19832—19833
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Priority Research Papers

Knockdown of Foxg1 in Sox9+ supporting cells increases the trans-differentiation of supporting cells into hair cells in the neonatal mouse utricle

Yuan Zhang, Shasha Zhang, Zhonghong Zhang, Ying Dong, Xiangyu Ma, Ruiying Qiang, Yin Chen, Xia Gao, Chunjie Zhao, Fangyi Chen, Shuangba He, Renjie Chai,
https://doi.org/10.18632/aging.104009 pp 19834—19851
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Metformin alters skeletal muscle transcriptome adaptations to resistance training in older adults

Ameya S. Kulkarni, Bailey D. Peck, R. Grace Walton, Philip A. Kern, Jessica C. Mar, Samuel T. Windham, Marcas M. Bamman, Nir Barzilai, Charlotte A. Peterson,
https://doi.org/10.18632/aging.104096 pp 19852—19866
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Research Papers

COVID-19
CD45: a critical regulator in immune cells to predict severe and non-severe COVID-19 patients

Mingming Jin, Nannan Shi, Meng Wang, Chunzi Shi, Shengjie Lu, Qing Chang, Shuang Sha, Yun Lin, Yingmin Chen, Hui Zhou, Kaiyi Liang, Xuyuan Huang, Yuxin Shi, Gang Huang,
https://doi.org/10.18632/aging.103941 pp 19867—19879
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COVID-19
Single-cell expression profiles of ACE2 and TMPRSS2 reveals potential vertical transmission and fetus infection of SARS-CoV-2

Mengdie Lü, Li Qiu, Guangshuai Jia, Rongqun Guo, Qibin Leng,
https://doi.org/10.18632/aging.104015 pp 19880—19897
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COVID-19
Comparison of clinical characteristics of COVID-19 between elderly patients and young patients: a study based on a 28-day follow-up

Lin Zhang, Tao Fan, Shuo Yang, Haojie Feng, Bo Hao, Zilong Lu, Rui Xiong, Xiaokang Shen, Wenyang Jiang, Wei Wang, Qing Geng,
https://doi.org/10.18632/aging.104077 pp 19898—19910
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COVID-19
Short telomeres increase the risk of severe COVID-19

Antoine Froidure, Manon Mahieu, Delphine Hoton, Pierre-François Laterre, Jean Cyr Yombi, Sandra Koenig, Benoit Ghaye, Jean-Philippe Defour, Anabelle Decottignies,
https://doi.org/10.18632/aging.104097 pp 19911—19922
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COVID-19
Influence of anti-osteoporosis treatments on the incidence of COVID-19 in patients with non-inflammatory rheumatic conditions

Josep Blanch-Rubió, Natalia Soldevila-Domenech, Laura Tío, Jone Llorente-Onaindia, Manuel Ciria-Recasens, Luciano Polino, Alba Gurt, Rafael de la Torre, Rafael Maldonado, Jordi Monfort, the Covidmar Study Group,
https://doi.org/10.18632/aging.104117 pp 19923—19937
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COVID-19
An improved multivariate model that distinguishes COVID-19 from seasonal flu and other respiratory diseases

Xing Guo, Yanrong Li, Hua Li, Xueqin Li, Xu Chang, Xuemei Bai, Zhanghong Song, Junfeng Li, Kefeng Li,
https://doi.org/10.18632/aging.104132 pp 19938—19944
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COVID-19
Lung ultrasound is a reliable diagnostic technique to predict abnormal CT chest scan and to detect oxygen requirements in COVID-19 pneumonia

Géraldine Falgarone, Frédéric Pamoukdjian, Johann Cailhol, Audrey Giocanti-Auregan, Sandrine Guis, Guilhem Bousquet, Olivier Bouchaud, Olivier Seror,
https://doi.org/10.18632/aging.104150 pp 19945—19953
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Identification of potential molecular pathways involved in prostate carcinogenesis in offspring exposed to maternal malnutrition

Sérgio Alexandre Alcantara Santos, Ana Carolina Lima Camargo, Flávia Bessi Constantino, Ketlin Thassiani Colombelli, Luiz Marcos Frediani Portela, Matheus Naia Fioretto, José Cavalcante Souza Vieira, Pedro Magalhães Padilha, Mateus Betta de Oliveira, Sergio Luis Felisbino, Robson Francisco Carvalho, Luis Antonio Justulin,
https://doi.org/10.18632/aging.104093 pp 19954—19978
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Interplay between gonadal hormones and postnatal overfeeding in defining sex-dependent differences in gut microbiota architecture

Jose A. Santos-Marcos, Alexia Barroso, Oriol A. Rangel-Zuñiga, Cecilia Perdices-Lopez, Carmen Haro, Miguel A. Sanchez-Garrido, Helena Molina-Abril, Claes Ohlsson, Pablo Perez-Martinez, Matti Poutanen, Jose Lopez-Miranda, Francisco Perez-Jimenez, Manuel Tena-Sempere, Antonio Camargo,
https://doi.org/10.18632/aging.104140 pp 19979—20000
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Systemic overexpression of C-C motif chemokine ligand 2 promotes metabolic dysregulation and premature death in mice with accelerated aging

Fedra Luciano-Mateo, Noemí Cabré, Gerard Baiges-Gaya, Salvador Fernández-Arroyo, Anna Hernández-Aguilera, Elisabet Elisabet Rodríguez-Tomàs, Meritxell Arenas, Jordi Camps, Javier A. Menéndez, Jorge Joven,
https://doi.org/10.18632/aging.104154 pp 20001—20023
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GDF11 induces mild hepatic fibrosis independent of metabolic health

Jan Frohlich, Kristina Kovacovicova, Tommaso Mazza, Maria R. Emma, Daniela Cabibi, Michelangelo Foti, Cyril Sobolewski, Jude A. Oben, Marion Peyrou, Francesc Villarroya, Maurizio Soresi, Rita Rezzani, Melchiorre Cervello, Francesca Bonomini, Anna Alisi, Manlio Vinciguerra,
https://doi.org/10.18632/aging.104182 pp 20024—20046
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CUEDC1 inhibits epithelial-mesenchymal transition via the TβRI/Smad signaling pathway and suppresses tumor progression in non-small cell lung cancer

Yue Cui, Yang Song, Shi Yan, Mengru Cao, Jian Huang, Dexin Jia, Yuechao Liu, Shuai Zhang, Weina Fan, Li Cai, Chunhong Li, Ying Xing,
https://doi.org/10.18632/aging.103329 pp 20047—20068
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LncRNA FAM181A-AS1 promotes gliomagenesis by sponging miR-129-5p and upregulating ZRANB2

Xin Jiang, Dong Chen,
https://doi.org/10.18632/aging.103391 pp 20069—20084
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Effect of ticagrelor versus clopidogrel on platelet reactivity measured by thrombelastography in patients with minor stroke or TIA

Yingying Yang, Weiqi Chen, Yuesong Pan, Hongyi Yan, Xia Meng, Liping Liu, Yongjun Wang, Yilong Wang,
https://doi.org/10.18632/aging.103452 pp 20085—20094
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Depressive and anxiety disorders worsen the prognosis of glioblastoma

Xiaojun Fu, Chenxing Wu, Ning Han, Ning Liu, Song Han, Xuebin Liu, Shouwei Li, Changxiang Yan,
https://doi.org/10.18632/aging.103593 pp 20095—20110
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MicroRNA-143 sensitizes acute myeloid leukemia cells to cytarabine via targeting ATG7- and ATG2B-dependent autophagy

Hao Zhang, Jianmin Kang, Ling Liu, Lulu Chen, Saisai Ren, Yanling Tao,
https://doi.org/10.18632/aging.103614 pp 20111—20126
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Long non-coding RNA DLEUI promotes papillary thyroid carcinoma progression by sponging miR-421 and increasing ROCK1 expression

Rui Li, Taihu Wan, Jie Qu, Yang Yu, Ruipeng Zheng,
https://doi.org/10.18632/aging.103642 pp 20127—20138
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Circular RNA circ_PVT1 induces epithelial-mesenchymal transition to promote metastasis of cervical cancer

Hongping Wang, Meiling Wei, Yihua Kang, Jianqin Xing, Yinghui Zhao,
https://doi.org/10.18632/aging.103679 pp 20139—20151
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Polymerase I and transcript release factor transgenic mice show impaired function of hematopoietic stem cells

Lin Bai, Ying Lyu, Guiying Shi, Keya Li, Yiying Huang, Yuanwu Ma, Yu-Sheng Cong, Lianfeng Zhang, Chuan Qin,
https://doi.org/10.18632/aging.103729 pp 20152—20162
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Down-regulated ciRS-7/up-regulated miR-7 axis aggravated cartilage degradation and autophagy defection by PI3K/AKT/mTOR activation mediated by IL-17A in osteoarthritis

Xindie Zhou, Jin Li, Yuanshuai Zhou, Zhicheng Yang, Haoyu Yang, Dong Li, Junjie Zhang, Yi Zhang, Nanwei Xu, Yong Huang, Lifeng Jiang,
https://doi.org/10.18632/aging.103731 pp 20163—20183
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Interleukin-6 knockout reverses macrophage differentiation imbalance and alleviates cardiac dysfunction in aging mice

Yuan Wang, Shan Zhu, Wen Wei, Yi Tu, Chuang Chen, Junlong Song, Juanjuan Li, Changhua Wang, Zhiliang Xu, Shengrong Sun,
https://doi.org/10.18632/aging.103749 pp 20184—20197
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Silencing of long non-coding RNA MEG3 alleviates lipopolysaccharide-induced acute lung injury by acting as a molecular sponge of microRNA-7b to modulate NLRP3

Handi Liao, Suning Zhang, Jianou Qiao,
https://doi.org/10.18632/aging.103752 pp 20198—20211
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LINC00265 targets miR-382-5p to regulate SAT1, VAV3 and angiogenesis in osteosarcoma

Ying Xiao, Chunling Li, Hongyue Wang, Yijun Liu,
https://doi.org/10.18632/aging.103762 pp 20212—20225
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Aerobic exercise induces tumor suppressor p16INK4a expression of endothelial progenitor cells in human skeletal muscle

Jinfu Wu, I-Shiung Cheng, Suchada Saovieng, Wei-Horng Jean, Chung-Lan Kao, Yung-Yang Liu, Chih-Yang Huang, Tania Xu Yar Lee, John L. Ivy, Chia-Hua Kuo,
https://doi.org/10.18632/aging.103763 pp 20226—20234
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ARHGEF11 promotes proliferation and epithelial-mesenchymal transition of hepatocellular carcinoma through activation of β-catenin pathway

Jinpeng Du, Zexin Zhu, Lin Xu, Xing Chen, Xuefeng Li, Tian Lan, Wei Li, Kefei Yuan, Yong Zeng,
https://doi.org/10.18632/aging.103772 pp 20235—20253
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Development and validation of an immune and stromal prognostic signature in uveal melanoma to guide clinical therapy

Qianwen Gong, Qi Wan, Anqi Li, Yubin Yu, Xiangyu Ding, Lei Lin, Xiaoliang Qi, Liang Hu,
https://doi.org/10.18632/aging.103779 pp 20254—20267
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TFG-maintaining stability of overlooked FANCD2 confers early DNA-damage response

Chi Ma, Kanani Hokutan, Yihang Shen, Manoj Nepal, Jin-Hee Kim, Jun Zhang, Peiwen Fei,
https://doi.org/10.18632/aging.103782 pp 20268—20284
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LncRNA DGCR5 plays a tumor-suppressive role in glioma via the miR-21/Smad7 and miR-23a/PTEN axes

Zongze He, Juan Long, Chen Yang, Bo Gong, Meixiong Cheng, Qi Wang, Jian Tang,
https://doi.org/10.18632/aging.103800 pp 20285—20307
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TRIM28 is a distinct prognostic biomarker that worsens the tumor immune microenvironment in lung adenocarcinoma

Jie Liu, Xiao Han, Lijuan Chen, Dong Han, Xiaoqian Mu, Xiufeng Hu, Hongbo Wu, Huijuan Wu, Wenjing Liu, Yanqiu Zhao,
https://doi.org/10.18632/aging.103804 pp 20308—20331
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Identification of long-term survival-associated gene in breast cancer

Shipeng Ning, Hui Li, Kun Qiao, Qin Wang, Meiying Shen, Yujuan Kang, Yanling Yin, Jiena Liu, Lei Liu, Siyu Hou, Jianyu Wang, Shouping Xu, Da Pang,
https://doi.org/10.18632/aging.103807 pp 20332—20349
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Blood-based biomarkers in hypothalamic-pituitary axes for the risk of dementia or cognitive decline: a systematic review and meta-analysis

Yi-Jun Ge, Wei Xu, Chen-Chen Tan, Lan Tan,
https://doi.org/10.18632/aging.103813 pp 20350—20365
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miR-140-3p inhibits bladder cancer cell proliferation and invasion by targeting FOXQ1

Yuan Wang, Junwen Chen, Xia Wang, Kefeng Wang,
https://doi.org/10.18632/aging.103828 pp 20366—20379
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Rab1A promotes cancer metastasis and radioresistance through activating GSK-3β/Wnt/β-catenin signaling in nasopharyngeal carcinoma

Xian-Zi Yang, Xi-Min Chen, Li-Si Zeng, Jin Deng, Lei Ma, Chuan Jin, Ren Wang, Meng-He Wang, Yue-Feng Wen, Xiao-Liang Wu, Hui-Yun Wang, Shu-Zhong Cui,
https://doi.org/10.18632/aging.103829 pp 20380—20395
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The oncogenic role of LncRNA FAM83C-AS1 in colorectal cancer development by epigenetically inhibits SEMA3F via stabilizing EZH2

Weinan Xue, Fan Wang, Peng Han, Yanlong Liu, Bomiao Zhang, Xinyue Gu, Yue Wang, Mingqi Li, Yashuang Zhao, Binbin Cui,
https://doi.org/10.18632/aging.103835 pp 20396—20412
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Systemic analyses of expression patterns and clinical features for GIMAPs family members in lung adenocarcinoma

Sisi Deng, Zhi Zhang, Xiaoli Lu, Qi Zhou, Shilin Xia, Mi Li,
https://doi.org/10.18632/aging.103836 pp 20413—20431
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Ku70 and Ku80 participate in LPS-induced pro-inflammatory cytokines production in human macrophages and monocytes

Hong Sun, Quan Li, Gang Yin, Xi Ding, Jing Xie,
https://doi.org/10.18632/aging.103845 pp 20432—20444
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Dual inhibition of DNA-PKcs and mTOR by CC-115 potently inhibits human renal cell carcinoma cell growth

Bing Zheng, Xu Sun, Xin-Feng Chen, Zhan Chen, Wei-li Zhu, Hua Zhu, Dong-Hua Gu,
https://doi.org/10.18632/aging.103847 pp 20445—20456
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Designing high affinity target-binding peptides to HLA-E: a key membrane antigen of multiple myeloma

Ying Yang, Mingli Sun, Zhaojin Yu, Jinwei Liu, Wei Yan, Zhuogang Liu, Minjie Wei, Hongtao Wang,
https://doi.org/10.18632/aging.103858 pp 20457—20470
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Development of a susceptibility gene based novel predictive model for the diagnosis of ulcerative colitis using random forest and artificial neural network

Hanyang Li, Lijie Lai, Jun Shen,
https://doi.org/10.18632/aging.103861 pp 20471—20482
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Accelerated telomere shortening independent of LRRK2 variants in Chinese patients with Parkinson's disease

Yue Wu, Yuqing Pei, Zhuo Yang, Kexin Li, Xiaoying Lou, Wei Cui,
https://doi.org/10.18632/aging.103878 pp 20483—20492
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RNA-seq reveals the diverse effects of substrate stiffness on epidermal ovarian cancer cells

Xiaoxu Yang, Guohui Wang, Xiaolei Huang, Min Cheng, Yangyang Han,
https://doi.org/10.18632/aging.103906 pp 20493—20511
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RWR-algorithm-based dissection of microRNA-506-3p and microRNA-140-5p as radiosensitive biomarkers in colorectal cancer

Fei Liao, Xin Chen, Pailan Peng, Weiguo Dong,
https://doi.org/10.18632/aging.103907 pp 20512—20522
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Exosomal long non-coding RNA UCA1 functions as growth inhibitor in esophageal cancer

Zijiang Zhu, Huilin Wang, Yao Pang, Hongxia Hu, Hongyi Zhang, Wenhao Wang,
https://doi.org/10.18632/aging.103911 pp 20523—20539
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Identification of a competing endogenous RNA axis related to gastric cancer

Fuqiang Zu, Hezhou Han, Weiwei Sheng, Jian Sun, Hui Zang, Yu Liang, Qingfeng Liu,
https://doi.org/10.18632/aging.103926 pp 20540—20560
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Colorectal cancer patients with CASK promotor heterogeneous and homogeneous methylation display different prognosis

Ying Liu, Hao Huang, Jinming Fu, Yuanyuan Zhang, Jing Xu, Lei Zhang, Simin Sun, Liyuan Zhao, Ding Zhang, Justina Ucheojor Onwuka, Hongru Sun, Binbin Cui, Yashuang Zhao,
https://doi.org/10.18632/aging.103928 pp 20561—20586
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Multiomics integrative analysis for gene signatures and prognostic values of m6A regulators in pancreatic adenocarcinoma: a retrospective study in The Cancer Genome Atlas project

Wenzhe Gao, Liuyang Cheng, Shuhan He, Wei Li, Chengyu Zhou, Bixia Zhou, Jiamiao Liu, Jiahao Xu, Xiao Yu, Hongwei Zhu,
https://doi.org/10.18632/aging.103942 pp 20587—20610
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Repetitive transcranial magnetic stimulation of the cerebellum improves ataxia and cerebello-fronto plasticity in multiple system atrophy: a randomized, double-blind, sham-controlled and TMS-EEG study

Penghui Song, Siran Li, Suobin Wang, Hua Wei, Hua Lin, Yuping Wang,
https://doi.org/10.18632/aging.103946 pp 20611—20622
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Improvement in sleep duration was associated with higher cognitive function: a new association

Jianian Hua, Hongpeng Sun, Yueping Shen,
https://doi.org/10.18632/aging.103948 pp 20623—20644
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Hsa_circ_0081534 increases the proliferation and invasion of nasopharyngeal carcinoma cells through regulating the miR-508-5p/FN1 axis

Sujuan Li, Qingshan Wang,
https://doi.org/10.18632/aging.103963 pp 20645—20657
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Cross-talk between the ER pathway and the lncRNA MAFG-AS1/miR-339-5p/ CDK2 axis promotes progression of ER+ breast cancer and confers tamoxifen resistance

Jing Feng, Ti Wen, Zhi Li, Liang Feng, Lu Zhou, Zichang Yang, Lu Xu, Sha Shi, Kezuo Hou, Jiming Shen, Xu Han, Yuee Teng,
https://doi.org/10.18632/aging.103966 pp 20658—20683
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Comprehensive analysis of cancer hallmarks in cutaneous melanoma and identification of a novel unfolded protein response as a prognostic signature

Qi Wan, Lin Jin, Zhichong Wang,
https://doi.org/10.18632/aging.103974 pp 20684—20701
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Stress-induced p53 drives BAG5 cochaperone expression to control α-synuclein aggregation in Parkinson's disease

Huan-Yun Chen, Chin-Hsien Lin, Shu-Chun Teng,
https://doi.org/10.18632/aging.103998 pp 20702—20727
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MicroRNA-338-5p alleviates neuronal apoptosis via directly targeting BCL2L11 in APP/PS1 mice

Junhua Li, Danhua Li, Huatao Zhou, Guiyun Wu, Zhijie He, Wenhua Liao, Yujuan Li, Yaowei Zhi,
https://doi.org/10.18632/aging.104005 pp 20728—20742
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Determination of the molecular mechanism by which macrophages and γδ-T cells contribute to ZOL-induced ONJ

Xingzhou Qu, Zhen Wang, Tian Zhou, Liancheng Shan,
https://doi.org/10.18632/aging.104006 pp 20743—20752
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Substance P blocks ovariectomy-induced bone loss by modulating inflammation and potentiating stem cell function

Jiyuan Piao, Jeong Seop Park, Dae Yeon Hwang, Youngsook Son, Hyun Sook Hong,
https://doi.org/10.18632/aging.104008 pp 20753—20777
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Identification of a nomogram based on an 8-lncRNA signature as a novel diagnostic biomarker for head and neck squamous cell carcinoma

Rui Mao, Yuanyuan Chen, Lei Xiong, Yanjun Liu, Tongtong Zhang,
https://doi.org/10.18632/aging.104014 pp 20778—20800
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Synergistic effect between LH and estrogen in the acceleration of cumulus expansion via GPR30 and EGFR pathways

Jie Liu, Ru Yao, Sihai Lu, Rui Xu, Hui Zhang, Juncai Wei, Chunrui Zhao, Yaju Tang, Chan Li, Haokun Liu, Xiaoe Zhao, Qiang Wei, Baohua Ma,
https://doi.org/10.18632/aging.104029 pp 20801—20816
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Hippocampal and cortical tissue-specific epigenetic clocks indicate an increased epigenetic age in a mouse model for Alzheimer’s disease

Emma Coninx, Yap Ching Chew, Xiaojing Yang, Wei Guo, Amelie Coolkens, Sarah Baatout, Lieve Moons, Mieke Verslegers, Roel Quintens,
https://doi.org/10.18632/aging.104056 pp 20817—20834
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SMARCD3 is a potential prognostic marker and therapeutic target in CAFs

Ming Jiang, Huiju Wang, Hong Chen, Yong Han,
https://doi.org/10.18632/aging.104102 pp 20835—20861
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TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer’s disease mice

Yaping Wang, Yan Lin, Linhan Wang, Hongrui Zhan, Xiaoting Luo, Yanyan Zeng, Wen Wu, Xingmei Zhang, Fang Wang,
https://doi.org/10.18632/aging.104104 pp 20862—20879
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SNCA Rep1 microsatellite length influences non-motor symptoms in early Parkinson’s disease

Alisa CW Yong, Yi Jayne Tan, Yi Zhao, Zhonghao Lu, Ebonne YL Ng, Samuel YE Ng, Nicole SY Chia, Xinyi Choi, Dede Heng, Shermyn Neo, Zheyu Xu, Kay Yaw Tay, Wing Lok Au, Eng-King Tan, Louis CS Tan, Adeline SL Ng,
https://doi.org/10.18632/aging.104111 pp 20880—20887
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Is cardiovascular fitness associated with structural brain integrity in midlife? Evidence from a population-representative birth cohort study

Tracy d’Arbeloff, Megan Cooke, Annchen R. Knodt, Maria Sison, Tracy R. Melzer, David Ireland, Richie Poulton, Sandhya Ramrakha, Terrie E. Moffitt, Avshalom Caspi, Ahmad R. Hariri,
https://doi.org/10.18632/aging.104112 pp 20888—20914
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Association of polymorphisms in ADAMTS-7 gene with the susceptibility to coronary artery disease - a systematic review and meta-analysis

Davood K. Hosseini, Sharareh Ataikia, Hanieh K. Hosseini, Baoai Han, Haiying Sun,
https://doi.org/10.18632/aging.104118 pp 20915—20923
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Living alone for people on dementia medication: related use of drugs

Evi Zafeiridi, Alan J. McMichael, A. Peter Passmore, Bernadette McGuinness,
https://doi.org/10.18632/aging.104125 pp 20924—20929
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Retraction

Retraction: miR-5089-5p suppresses castration-resistant prostate cancer resistance to enzalutamide and metastasis via miR-5089-5p/SPINK1/ MAPK/MMP9 signaling

Zhi-Chao Wang, Yan Li, Ke-Liang Wang, Lu Wang, Bo-Sen You, Dan-Feng Zhao, Zhong- Qing Liu, Rui-Zhe Fang, Jia-Qi Wang, Wei Zhang, Jin-Ming Zhang, Wan-Hai Xu,
https://doi.org/10.18632/aging.104212 pp 20930
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