Research Paper Volume 12, Issue 18 pp 18716—18740
Identification of robust genetic signatures associated with lipopolysaccharide-induced acute lung injury onset and astaxanthin therapeutic effects by integrative analysis of RNA sequencing data and GEO datasets
Figure 2. Meta-analysis of five microarrays to identify genes related to LPS induction. (A) Flowchart of the meta-analysis approach. (B) Venn diagram of differentially expressed genes identified by the meta-analysis using Fisher's method, the vote-counting method, and a fixed-effect model. (C) Heat map visualization of the top 50 consistently differentially expressed genes (either completely upregulated or downregulated) across the five microarrays identified by the meta-analysis (row-wise comparison).