Research Paper Volume 12, Issue 23 pp 23917—23930

Figure 2. Consensus matrix for DNA methylation classification with the corresponding heat map. (A) Color-coded heatmap corresponding to the consensus matrix for k=7 obtained by applying consensus clustering. Color gradients represent consensus values from 0–1; white corresponds to 0 and dark blue to 1. To aid analysis, the cluster memberships are marked by colored rectangles between the dendrogram and heatmap according to a legend within the graphic. This enables a user to compare a clusters’ member count in the context of their consensus. (B) A heatmap corresponding to the dendrogram in (A) was generated using the heatmap function with DNA methylation classification, TNM stage, clinicopathological stage, age, and gender as the annotations.