Priority Research Paper Volume 12, Issue 20 pp 19852—19866

Figure 1. Metformin blunts the global transcriptomic changes induced by PRT in human skeletal muscle. (A) Volcano plot of 2048 DEG (q-value < 0.01) with plaPRT between 16 weeks and baseline; (B) Volcano plot of 1435 DEG (q-value < 0.01) with metPRT intervention between 16 weeks and baseline; (C) Principal component analysis on DEG shared between plaPRT (orange) and metPRT (green) compared to baseline (blue); (D) Venn diagram showing an overlap of DEG common between plaPRT and metPRT vs baseline; (E) Correlation plot between the fold changes of DEG common between plaPRT and metPRT.