Is cardiovascular fitness associated with structural brain integrity in midlife? Evidence from a population-representative birth cohort study

Figure 4.Cortical surface area (cm^{2}) at age 45 and rate of decline in VO_{2}Max scores (mL/min/Kg) from age 26 to 45. (A) Surface area. (B) Graph showing the correlation between total surface area (cm^{2}, y-axis) and the rate of decline in VO_{2}Max (average decrease in mL/min/kg between each wave of data collection; x-axis). Study members with VO_{2}Max scores declining at a faster rate over time (i.e., larger slopes) did have slightly smaller total surface area (β = -0.09, 95% CI = -0.17 to -0.004, p=0.04). There were no regionally-specific associations. cm^{3} = centimeters cubed; VO_{2}Max = volume of maximum oxygen uptake; mL/min/kg = milliliters per minute per kilogram; β = standardized coefficient; CI = confidence interval.