Reduced SULT2B1b expression alleviates ox-LDL-induced inflammation by upregulating miR-148-3P via inhibiting the IKKβ/NF-κB pathway in macrophages

Mengzhuo Yin; Jianwen Lu; Zhongzhou Guo; Yanan Zhang; Jichen Liu; Tongwei Wu; Kai Guo; Tiantian Luo; Zhigang Guo

doi:doi:10.18632/aging.202273

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Research Paper Volume 13, Issue 3 pp 3428—3442

Reduced SULT2B1b expression alleviates ox-LDL-induced inflammation by upregulating miR-148-3P via inhibiting the IKKβ/NF-κB pathway in macrophages

Figure 2. SULT2B1b impedes miR-148a-3p expression in macrophages. (A) The volcano plot of miRNA profiles represents the significantly up/downregulated miRNAs in RAW264.7 cells transfected with or without Ad-shSULT2B1b. (B) Upregulated miRNA expression (miR-129-5p, miR-6995-3p, miR-155-3p, miR-148a-3p and miR-192-5p) was detected by RT-qPCR. (C) After transfection with Ad-shSULT2B1b and following stimulation with ox-LDL, miR-148a-3p levels significantly increased among the miRNAs. Data are shown as the mean±SD (n=4). **p<0.01, ***p<0.001. ns, no significant difference.