Online ISSN: 1945-4589

Volume 13, Issue 3

15 February, 2021
pp 3165—4733

About the Cover

The cover features Figure 1 "Rapamycin extends lifespan in natural but not progeroid mice“ from Blagosklonny


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Table of Contents

Editorial

Glutamine, fatty liver disease and aging

Jorge Simón, María Luz Martínez-Chantar, Teresa C. Delgado,
https://doi.org/10.18632/aging.202666 pp 3165—3166
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Research Perspective

DNA- and telomere-damage does not limit lifespan: evidence from rapamycin

Mikhail V. Blagosklonny,
https://doi.org/10.18632/aging.202674 pp 3167—3175
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Research Papers

COVID-19
Development and validation of a prognostic nomogram for predicting in-hospital mortality of COVID-19: a multicenter retrospective cohort study of 4086 cases in China

Li Li, Xiaoyu Fang, Lixia Cheng, Penghao Wang, Shen Li, Hao Yu, Yao Zhang, Nan Jiang, Tingting Zeng, Chao Hou, Jing Zhou, Shiru Li, Yingzi Pan, Yitong Li, Lili Nie, Yang Li, Qidi Sun, Hong Jia, Mengxia Li, Guoqiang Cao, Xiangyu Ma,
https://doi.org/10.18632/aging.202605 pp 3176—3189
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COVID-19
The age pattern of the male-to-female ratio in mortality from COVID-19 mirrors that of cardiovascular disease in the general population

Ila Nimgaonkar, Linda Valeri, Ezra Susser, Sabiha Hussain, Jag Sunderram, Abraham Aviv,
https://doi.org/10.18632/aging.202639 pp 3190—3201
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GV1001 interacts with androgen receptor to inhibit prostate cell proliferation in benign prostatic hyperplasia by regulating expression of molecules related to epithelial-mesenchymal transition

Yejin Kim, Dahae Lee, Hyejung Jo, Cheolhyeon Go, Jongwon Yang, Dongmin Kang, Jae Seung Kang,
https://doi.org/10.18632/aging.202242 pp 3202—3217
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Brain microstructure mediates sex-specific patterns of cognitive aging

Emilie T. Reas, Donald J. Hagler, Allison J. Zhong, Roland R. Lee, Anders M. Dale, Linda K. McEvoy,
https://doi.org/10.18632/aging.202561 pp 3218—3238
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Uncovering molecular mechanisms of regulated cell death in the naked mole rat

Alexei Evdokimov, Alexei Popov, Elena Ryabchikova, Olga Koval, Svetlana Romanenko, Vladimir Trifonov, Irina Petruseva, Inna Lavrik, Olga Lavrik,
https://doi.org/10.18632/aging.202577 pp 3239—3253
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Examining sleep deficiency and disturbance and their risk for incident dementia and all-cause mortality in older adults across 5 years in the United States

Rebecca Robbins, Stuart F. Quan, Matthew D. Weaver, Gregory Bormes, Laura K. Barger, Charles A. Czeisler,
https://doi.org/10.18632/aging.202591 pp 3254—3268
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Geroprotective effects of Alzheimer’s disease drug candidates

Devin Kepchia, Antonio Currais, Richard Dargusch, Kim Finley, David Schubert, Pamela Maher,
https://doi.org/10.18632/aging.202631 pp 3269—3289
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Suppression of p16 alleviates the senescence-associated secretory phenotype

Raquel Buj, Kelly E. Leon, Marlyn A. Anguelov, Katherine M. Aird,
https://doi.org/10.18632/aging.202640 pp 3290—3312
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Ageing transcriptome meta-analysis reveals similarities and differences between key mammalian tissues

Daniel Palmer, Fabio Fabris, Aoife Doherty, Alex A. Freitas, João Pedro de Magalhães,
https://doi.org/10.18632/aging.202648 pp 3313—3341
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The DNA methylation-regulated MCTP1 activates the drug-resistance of esophageal cancer cells

Lingsuo Kong, Wan Yang, Lanren Chen, Liting Qian,
https://doi.org/10.18632/aging.104173 pp 3342—3352
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Asiatic acid protects oocytes against in vitro aging-induced deterioration and improves subsequent embryonic development in pigs

Wei-Yi Hu, Xiao Xia Li, Yun Fei Diao, Jia-Jia Qi, Da-Li Wang, Jia-Bao Zhang, Bo-Xing Sun, Shuang Liang,
https://doi.org/10.18632/aging.202184 pp 3353—3367
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Amorphous nano-selenium quantum dots prevent pulmonary arterial hypertension through recoupling endothelial nitric oxide synthase

Mo-Li Zhu, Zhi-Tao Gao, Jun-Xiu Lu, Yang Wang, Ge Wang, Tian-Tian Zhu, Peng Li, Chao Liu, Shuang-Xi Wang, Lin Yang,
https://doi.org/10.18632/aging.202215 pp 3368—3385
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Tumor-associated macrophages promote pancreatic ductal adenocarcinoma progression by inducing epithelial-to-mesenchymal transition

Cheng Xiong, Youwei Zhu, Meilin Xue, Yongsheng Jiang, Yiming Zhong, Lingxi Jiang, Minmin Shi, Hao Chen,
https://doi.org/10.18632/aging.202264 pp 3386—3404
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PTP1B inhibitor alleviates deleterious microglial activation and neuronal injury after ischemic stroke by modulating the ER stress-autophagy axis via PERK signaling in microglia

Yu Zhu, Jianbo Yu, Jiangbiao Gong, Jie Shen, Di Ye, Dexin Cheng, Zhikai Xie, Jianping Zeng, Kangli Xu, Jian Shen, Hengjun Zhou, Yuxiang Weng, Jianwei Pan, Renya Zhan,
https://doi.org/10.18632/aging.202272 pp 3405—3427
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Reduced SULT2B1b expression alleviates ox-LDL-induced inflammation by upregulating miR-148-3P via inhibiting the IKKβ/NF-κB pathway in macrophages

Mengzhuo Yin, Jianwen Lu, Zhongzhou Guo, Yanan Zhang, Jichen Liu, Tongwei Wu, Kai Guo, Tiantian Luo, Zhigang Guo,
https://doi.org/10.18632/aging.202273 pp 3428—3442
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Hypoxia-inducible factor 2-alpha-dependent induction of IL-6 protects the heart from ischemia/reperfusion injury

Jia-Wei Wu, Hao Hu, Dan Li, Li-Kun Ma,
https://doi.org/10.18632/aging.202276 pp 3443—3458
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Exploration of the immune cell infiltration-related gene signature in the prognosis of melanoma

Yangyang Zeng, Yulan Zeng, Hang Yin, Fengxia Chen, Qingqing Wang, Xiaoyan Yu, Yunfeng Zhou,
https://doi.org/10.18632/aging.202279 pp 3459—3482
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Estradiol is significantly associated with prognosis in non-surgical liver cancer patients: from bench to bedside

Rangrang Wang, Yuan Liu, Hongze Sun, Tao Wang, Changcan Li, Junwei Fan, Zhaowen Wang,
https://doi.org/10.18632/aging.202280 pp 3483—3500
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A novel Foxp3-related immune prognostic signature for glioblastoma multiforme based on immunogenomic profiling

Xiao-Yu Guo, Guan-Hua Zhang, Zhen-Ning Wang, Hao Duan, Tian Xie, Lun Liang, Rui Cui, Hong-Rong Hu, Yi Wu, Jia-jun Dong, Zhen-Qiang He, Yong-Gao Mou,
https://doi.org/10.18632/aging.202282 pp 3501—3517
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High expression of RRM2 as an independent predictive factor of poor prognosis in patients with lung adenocarcinoma

Cheng-Yu Jin, Liang Du, A-Han Nuerlan, Xiao-Lei Wang, Yong-Wei Yang, Rui Guo,
https://doi.org/10.18632/aging.202292 pp 3518—3535
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Identification of HIPK3 as a potential biomarker and an inhibitor of clear cell renal cell carcinoma

Wen Xiao, Tao Wang, Yuzhong Ye, Xuegang Wang, Bin Chen, Jinchun Xing, Hongmei Yang, Xiaoping Zhang,
https://doi.org/10.18632/aging.202294 pp 3536—3553
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ESRP1 regulates alternative splicing of CARM1 to sensitize small cell lung cancer cells to chemotherapy by inhibiting TGF-β/Smad signaling

Meng Zheng, Yuchun Niu, Junguo Bu, Shumei Liang, Zhilin Zhang, Jianhua Liu, Linlang Guo, Zhihua Zhang, Qiongyao Wang,
https://doi.org/10.18632/aging.202295 pp 3554—3572
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Late-onset epilepsy and subsequent increased risk of dementia

Zhi-Ren Tsai, Han-Wei Zhang, Chun-Hung Tseng, Hsiao-Ching Peng, Victor C. Kok, Gao Ping Li, Chao A. Hsiung, Chun-Yi. Hsu,
https://doi.org/10.18632/aging.202299 pp 3573—3587
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Downregulation of circFASTKD1 ameliorates myocardial infarction by promoting angiogenesis

Wen-Qing Gao, Xiao-Min Hu, Qiang Zhang, Lan Yang, Xin-Ze Lv, Shuang Chen, Peng Wu, Da-Wei Duan, Yu-Heng Lang, Meng Ning, Ke-Guan Lai, Zhi-Yuan Zhang, Bin Liang, Jing-Yu Bao, Hai-Dong Wu, Tong Li,
https://doi.org/10.18632/aging.202305 pp 3588—3604
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Platelet-derived biomaterials-mediated improvement of bone injury through migratory ability of embryonic fibroblasts: in vitro and in vivo evidence

Yen-Ru Chou, Wen-Cheng Lo, Navneet Kumar Dubey, Jui-Hua Lu, Hen-Yu Liu, Ching-Yu Tsai, Yue-Hua Deng, Chi-Ming Wu, Mao-Suan Huang, Win-Ping Deng,
https://doi.org/10.18632/aging.202311 pp 3605—3617
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Identification of novel SNPs associated with coronary artery disease and birth weight using a pleiotropic cFDR method

Xinrui Wu, Xu Lin, Qi Li, Zun Wang, Na Zhang, Mengyuan Tian, Xiaolei Wang, Hongwen Deng, Hongzhuan Tan,
https://doi.org/10.18632/aging.202322 pp 3618—3644
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Enrichment of branched chain amino acid transaminase 1 correlates with multiple biological processes and contributes to poor survival of IDH1 wild-type gliomas

Li Yi, Xiaoguang Fan, Jiabo Li, Feng Yuan, Jian Zhao, Monica Nistér, Xuejun Yang,
https://doi.org/10.18632/aging.202328 pp 3645—3660
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NFAT5 directs hyperosmotic stress-induced fibrin deposition and macrophage infiltration via PAI-1 in endothelium

Pingping Ma, Guang Li, Xiaorui Jiang, Xinkun Shen, Hong Li, Li Yang, Wanqian Liu,
https://doi.org/10.18632/aging.202330 pp 3661—3679
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Polyglutamine-expanded ataxin3 alter specific gene expressions through changing DNA methylation status in SCA3/MJD

Dongxue Ding, Chunrong Wang, Zhao Chen, Kun Xia, Beisha Tang, Rong Qiu, Hong Jiang,
https://doi.org/10.18632/aging.202331 pp 3680—3698
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Dexrazoxane ameliorates radiation-induced heart disease in a rat model

Long Li, Xiaoqi Nie, Peng Zhang, Yongbiao Huang, Li Ma, Fang Li, Minxiao Yi, Wan Qin, Xianglin Yuan,
https://doi.org/10.18632/aging.202332 pp 3699—3711
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Advanced paternal age and risk of cancer in offspring

Yangyang Sun, Xu Li, Wei Jiang, Yuanming Fan, Qiong Ouyang, Wei Shao, Raphael N. Alolga, Yuqiu Ge, Gaoxiang Ma,
https://doi.org/10.18632/aging.202333 pp 3712—3725
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SphK1-targeted miR-6784 inhibits functions of skin squamous cell carcinoma cells

Zhen-Hua Gong, Jiang Ji, Jian Yao, Jian-Feng Ji, Yasu Jiang, Gang Gao, Zhou Feng,
https://doi.org/10.18632/aging.202336 pp 3726—3741
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Key microRNAs and hub genes associated with poor prognosis in lung adenocarcinoma

Guan-Chao Ye, Ya-Fei Liu, Lan Huang, Chun-Yang Zhang, Yin-Liang Sheng, Bin Wu, Lu Han, Chun-Li Wu, Bo Dong, Yu Qi,
https://doi.org/10.18632/aging.202337 pp 3742—3762
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Dl-3-n-butylphthalide inhibits neuroinflammation by stimulating foxp3 and Ki-67 in an ischemic stroke model

Xi Liu, Runzhe Liu, Dongxu Fu, Hao Wu, Xin Zhao, Yi Sun, Meng Wang, Xiaoping Pu,
https://doi.org/10.18632/aging.202338 pp 3763—3778
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Long noncoding RNA TPT1-AS1 promotes the progression and metastasis of colorectal cancer by upregulating the TPT1-mediated FAK and JAK-STAT3 signalling pathways

Leiyi Zhang, Fei Ye, Zhongkun Zuo, Ding Cao, Yu Peng, Zedong Li, Jiangsheng Huang, Lunxi Duan,
https://doi.org/10.18632/aging.202339 pp 3779—3797
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Deciphering the correlations between aging and constipation by metabolomics and network pharmacology

Xiaojie Liu, Di Zhao, Sijun Zhao, Zhenyu Li, Yulan Wang, Xuemei Qin,
https://doi.org/10.18632/aging.202340 pp 3798—3818
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Four hub genes regulate tumor infiltration by immune cells, antitumor immunity in the tumor microenvironment, and survival outcomes in lung squamous cell carcinoma patients

Tuo Zhang, Haitang Yang, Beibei Sun, Feng Yao,
https://doi.org/10.18632/aging.202351 pp 3819—3842
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Cell lineage-specific methylome and genome alterations in gout

Chia-Chun Tseng, Wei-Ting Liao, Man-Chun Wong, Chung-Jen Chen, Su-Chen Lee, Jeng-Hsien Yen, Shun-Jen Chang,
https://doi.org/10.18632/aging.202353 pp 3843—3865
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Long intergenic non-coding RNA LINC00485 exerts tumor-suppressive activity by regulating miR-581/EDEM1 axis in colorectal cancer

Chenmeng Li, Bei Pan, Xiangxiang Liu, Jian Qin, Xuhong Wang, Bangshun He, Yuqin Pan, Huiling Sun, Tao Xu, Xueni Xu, Kaixuan Zeng, Shukui Wang,
https://doi.org/10.18632/aging.202354 pp 3866—3885
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Praja2 suppresses the growth of gastric cancer by ubiquitylation of KSR1 and inhibiting MEK-ERK signal pathways

Zhiwei Zhao, Lin Zhu, Yanwei Xing, Zhenan Zhang,
https://doi.org/10.18632/aging.202356 pp 3886—3897
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Intranasal treatment of lixisenatide attenuated emotional and olfactory symptoms via CREB-mediated adult neurogenesis in mouse depression model

Guoyong Ren, Pan Xue, Bin Wu, Fei Yang, Xuemei Wu,
https://doi.org/10.18632/aging.202358 pp 3898—3908
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Dysregulation of USP18/FTO/PYCR1 signaling network promotes bladder cancer development and progression

Wei Song, Ke Yang, Jianjun Luo, Zhiyong Gao, Yunliang Gao,
https://doi.org/10.18632/aging.202359 pp 3909—3925
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Development of prognostic signature based on RNA binding proteins related genes analysis in clear cell renal cell carcinoma

Qiang Chen, Zhi-Long Li, Sheng-Qiang Fu, Si-Yuan Wang, Yu-Tang Liu, Ming Ma, Xiao-Rong Yang, Wen-Jie Xie, Bin-Bin Gong, Ting Sun,
https://doi.org/10.18632/aging.202360 pp 3926—3944
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MicroRNA-205-5p targets the HOXD9-Snail1 axis to inhibit triple negative breast cancer cell proliferation and chemoresistance

Li-Fen Lin, Yi-Ting Li, Hui Han, Shun-Guo Lin,
https://doi.org/10.18632/aging.202363 pp 3945—3956
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Gene signatures of 6-methyladenine regulators in women with lung adenocarcinoma and development of a risk scoring system: a retrospective study using the cancer genome atlas database

Chundi Gao, Jing Zhuang, Huayao Li, Cun Liu, Chao Zhou, Lijuan Liu, Fubin Feng, Changgang Sun,
https://doi.org/10.18632/aging.202364 pp 3957—3968
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Transcriptomic characterization reveals prognostic molecular signatures of sorafenib resistance in hepatocellular carcinoma

Wei Yuan, Ran Tao, Da Huang, Weiming Yan, Guanxin Shen, Qin Ning,
https://doi.org/10.18632/aging.202365 pp 3969—3993
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Antiplatelet effect of ticagrelor with aspirin in acute minor stroke and transient ischemic attack stratified by CYP2C19 metabolizer status: subgroup analysis of the PRINCE trial

Mengyuan Zhou, Weiqi Chen, Yuesong Pan, Yi Lin, Xia Meng, Xingquan Zhao, Liping Liu, Jinxi Lin, Hao Li, Yongjun Wang, Yilong Wang,
https://doi.org/10.18632/aging.202366 pp 3994—4006
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Cortical thickness in Parkinson's disease: a coordinate-based meta-analysis

LiQin Sheng, PanWen Zhao, HaiRong Ma, Joaquim Radua, ZhongQuan Yi, YuanYuan Shi, JianGuo Zhong, ZhenYu Dai, PingLei Pan,
https://doi.org/10.18632/aging.202368 pp 4007—4023
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Identification of candidate genes encoding tumor-specific neoantigens in early- and late-stage colon adenocarcinoma

Chong Wang, Wenhua Xue, Haohao Zhang, Yang Fu,
https://doi.org/10.18632/aging.202370 pp 4024—4044
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ALKBH5-mediated m6A demethylation of FOXM1 mRNA promotes progression of uveal melanoma

Lili Hao, Jiayang Yin, Hong Yang, Chaoxuan Li, Linxin Zhu, Lian Liu, Jingxiang Zhong,
https://doi.org/10.18632/aging.202371 pp 4045—4062
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PRPS1-mediated purine biosynthesis is critical for pluripotent stem cell survival and stemness

Yi Yang, Lili Song, Xia Huang, Yanan Feng, Yingwen Zhang, Yanfeng Liu, Shanshan Li, Zhiyan Zhan, Liang Zheng, Haizhong Feng, Yanxin Li,
https://doi.org/10.18632/aging.202372 pp 4063—4078
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Microglia exosomal miRNA-137 attenuates ischemic brain injury through targeting Notch1

Dianquan Zhang, Guoliang Cai, Kai Liu, Zhe Zhuang, Kunping Jia, Siying Pei, Xiuzhen Wang, Hong Wang, Shengnan Xu, Cheng Cui, Manchao Sun, Sihui Guo, Wenli Song, Guofeng Cai,
https://doi.org/10.18632/aging.202373 pp 4079—4095
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Expression and prognostic analyses of SCAMPs in pancreatic adenocarcinoma

Feiyu Mao, Heng Duan, Aly Allamyradov, Zechang Xin, Yan Du, Xiaodong Wang, Peng Xu, Zhennan Li, Jianjun Qian, Jie Yao,
https://doi.org/10.18632/aging.202377 pp 4096—4114
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LncRNA XIST sponges miR-199a-3p to modulate the Sp1/LRRK2 signal pathway to accelerate Parkinson’s disease progression

Qian Zhou, Ming-Ming Zhang, Min Liu, Zhi-Gang Tan, Qi-Lin Qin, Yu-Gang Jiang,
https://doi.org/10.18632/aging.202378 pp 4115—4137
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Diagnostic and prognostic values of AKR1C3 and AKR1D1 in hepatocellular carcinoma

Pengfei Zhu, Ruo Feng, Xu Lu, Yuan Liao, Zhicheng Du, Wenlong Zhai, Kunlun Chen,
https://doi.org/10.18632/aging.202380 pp 4138—4156
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CCDC167 as a potential therapeutic target and regulator of cell cycle-related networks in breast cancer

Pin-Shern Chen, Hui-Ping Hsu, Nam Nhut Phan, Meng-Chi Yen, Feng-Wei Chen, Yu-Wei Liu, Fang-Ping Lin, Sheng-Yao Feng, Tsung-Lin Cheng, Pei-Hsiang Yeh, Hany A. Omar, Zhengda Sun, Jia-Zhen Jiang, Yi-Shin Chan, Ming-Derg Lai, Chih-Yang Wang, Jui-Hsiang Hung,
https://doi.org/10.18632/aging.202382 pp 4157—4181
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Comprehensive analysis of lncRNAs N6-methyladenosine modification in colorectal cancer

Luo Zuo, Hui Su, Qiao Zhang, Wei-yu Wu, Yan Zeng, Xue-mei Li, Jing Xiong, Lan-fang Chen, Yan Zhou,
https://doi.org/10.18632/aging.202383 pp 4182—4198
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Long non-coding RNA (LncRNA) HOTAIR regulates BMP9-induced osteogenic differentiation by targeting the proliferation of mesenchymal stem cells (MSCs)

Ruidong Li, Wenwen Zhang, Zhengjian Yan, Wei Liu, Jiaming Fan, Yixiao Feng, Zongyue Zeng, Daigui Cao, Rex C. Haydon, Hue H. Luu, Zhong-Liang Deng, Tong-Chuan He, Yulong Zou,
https://doi.org/10.18632/aging.202384 pp 4199—4214
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RNA interactions in right ventricular dysfunction induced type II cardiorenal syndrome

Kaitong Chen, Xiaoxia Huang, Dongxiao Xie, Mengjia Shen, Hairuo Lin, Yingqi Zhu, Siyuan Ma, Cankun Zheng, Lu Chen, Yameng Liu, Wangjun Liao, Jianping Bin, Yulin Liao,
https://doi.org/10.18632/aging.202385 pp 4215—4241
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Oxaliplatin induces the PARP1-mediated parthanatos in oral squamous cell carcinoma by increasing production of ROS

Dongfang Li, Yuying Kou, Yuan Gao, Shanshan Liu, Panpan Yang, Tomoka Hasegawa, Rongjian Su, Jie Guo, Minqi Li,
https://doi.org/10.18632/aging.202386 pp 4242—4257
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Cross-platform genomic identification and clinical validation of breast cancer diagnostic biomarkers

Dongdong Liu, Beibei Li, Xiaoshun Shi, Jiexia Zhang, Allen Menglin Chen, Jiarui Xu, Wan Wang, Kailing Huang, Jinwei Gao, Zhouxia Zheng, Dan Liu, Huimin Wang, Wen Shi, Lin Chen, Jianhua Xu,
https://doi.org/10.18632/aging.202388 pp 4258—4273
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The roles of PARP-1 and XPD and their potential interplay in repairing bupivacaine-induced neuron oxidative DNA damage

Wei Zhao, Zhongjie Liu, Jiaming Luo, Changqing Ma, Luying Lai, Zhengyuan Xia, Shiyuan Xu,
https://doi.org/10.18632/aging.202390 pp 4274—4290
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Histological characteristics of bone in-growth of proximal humeral implants with different spatial structures

Zhe Xue, Zheng Pei, Hui Zhang, Chong Tang, Junxiu Jia, Kun Zhang, Keshi Zhang, Luning Wang, Zhenpeng Guan,
https://doi.org/10.18632/aging.202391 pp 4291—4298
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Overexpression of long noncoding RNA ANRIL inhibits phenotypic switching of vascular smooth muscle cells to prevent atherosclerotic plaque development in vivo

Da-Jun Hu, Zhen-Yu Li, Yuan-Ting Zhu, Chuan-Chang Li,
https://doi.org/10.18632/aging.202392 pp 4299—4316
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The landscape of alternative splicing reveals novel events associated with tumorigenesis and the immune microenvironment in gastric cancer

Shenghan Lou, Jian Zhang, Zhao Zhai, Xin Yin, Yimin Wang, Tianyi Fang, Yingwei Xue,
https://doi.org/10.18632/aging.202393 pp 4317—4334
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CUEDC2 ablation enhances the efficacy of mesenchymal stem cells in ameliorating cerebral ischemia/reperfusion insult

Yan Huang, Xia Xiao, Han Xiao, Zhiping Hu, Fengbo Tan,
https://doi.org/10.18632/aging.202394 pp 4335—4356
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The hepatic microenvironment promotes lung adenocarcinoma cell proliferation, metastasis, and epithelial–mesenchymal transition via METTL3-mediated N6-methyladenosine modification of YAP1

Xue-Feng Ni, Quan-Qin Xie, Jie-Min Zhao, Yan-jie Xu, Mei Ji, Wen-Wei Hu, Jun Wu, Chang-Ping Wu,
https://doi.org/10.18632/aging.202397 pp 4357—4369
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Adipose-derived stromal cells improve functional recovery after spinal cord injury through TGF-β1/Smad3/PLOD2 pathway activation

Fang Li, Hua Liu, Kun Zhang, Dong-Jie Xiao, Chang Wang, Yun-Shan Wang,
https://doi.org/10.18632/aging.202399 pp 4370—4387
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Lumican inhibits immune escape and carcinogenic pathways in colorectal adenocarcinoma

Yiqing Zang, Qiuping Dong, Yi Lu, Kaiti Dong, Rong Wang, Zheng Liang,
https://doi.org/10.18632/aging.202401 pp 4388—4408
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Myeloid differentiation 2 deficiency attenuates AngII-induced arterial vascular oxidative stress, inflammation, and remodeling

Shushi Huang, Shengban You, Jinfu Qian, Chengyi Dai, Siyuan Shen, Jun Wang, Weijian Huang, Guang Liang, Gaojun Wu,
https://doi.org/10.18632/aging.202402 pp 4409—4427
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Tsukushi is a novel prognostic biomarker and correlates with tumor-infiltrating B cells in non-small cell lung cancer

Hao Huang, Ding Zhang, Jinming Fu, Liyuan Zhao, Dapeng Li, Hongru Sun, Xinyan Liu, Jing Xu, Tian Tian, Lei Zhang, Ying Liu, Yuanyuan Zhang, Yashuang Zhao,
https://doi.org/10.18632/aging.202403 pp 4428—4451
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Modeling paraquat-induced lung fibrosis in C. elegans reveals KRIT1 as a key regulator of collagen gene transcription

Gongping Deng, Le Li, Yanhong Ouyang,
https://doi.org/10.18632/aging.202406 pp 4452—4467
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PRMT5 regulates colorectal cancer cell growth and EMT via EGFR/Akt/GSK3β signaling cascades

Yongrong Yan, Peipei Zhao, Zihuan Wang, Zhen Liu, Zhizhi Wang, Jinglan Zhang, Yanqing Ding, Xing Hua, Lina Yu,
https://doi.org/10.18632/aging.202407 pp 4468—4481
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Identification of downstream signaling cascades of ACK1 and prognostic classifiers in non-small cell lung cancer

Jinhong Zhu, Yang Liu, Meng Zhao, Kui Cao, Jianqun Ma, Shiyun Peng,
https://doi.org/10.18632/aging.202408 pp 4482—4502
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Identification of therapeutic targets and prognostic biomarkers from the hnRNP family in invasive breast carcinoma

Jiawei Zhou, Yugang Guo, Zheng Huo, Yuxin Xing, Jintao Fang, Guohui Ma, Qinghui Han, Mengzhen Wang, Qian Xu,
https://doi.org/10.18632/aging.202411 pp 4503—4521
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Hsa_circ_0000199 facilitates chemo-tolerance of triple-negative breast cancer by interfering with miR-206/613-led PI3K/Akt/mTOR signaling

Hongchang Li, Wen Xu, Zhihua Xia, Weiyan Liu, Gaofeng Pan, Junbin Ding, Jindong Li, Jianfa Wang, Xiaofeng Xie, Daowen Jiang,
https://doi.org/10.18632/aging.202415 pp 4522—4551
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Cognitive function and its influencing factors in empty-nest elderly and non-empty-nest elderly adults in China

Fan Yang, Zhen Li, Guo-Wen Wang, Xiu-Xin Shi, Chang Fu,
https://doi.org/10.18632/aging.202416 pp 4552—4563
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Overexpression of TICRR and PPIF confer poor prognosis in endometrial cancer identified by gene co-expression network analysis

Linlin Yang, Yunxia Cui, Xiao Sun, Yudong Wang,
https://doi.org/10.18632/aging.202417 pp 4564—4589
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Decreased miR-132 plays a crucial role in diabetic encephalopathy by regulating the GSK-3β/Tau pathway

Li Shi, Rui Zhang, Tian Li, Xue Han, Nannan Yuan, Lei Jiang, Huimin Zhou, Shunjiang Xu,
https://doi.org/10.18632/aging.202418 pp 4590—4604
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Resveratrol alleviates bleomycin-induced pulmonary fibrosis via suppressing HIF-1α and NF-κB expression

Zaiyan Wang, Xiaoning Li, Hao Chen, Li Han, Xiaobin Ji, Qiubo Wang, Li Wei, Yafang Miu, Jing Wang, Jianfeng Mao, Zeming Zhang,
https://doi.org/10.18632/aging.202420 pp 4605—4616
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LNK promotes granulosa cell apoptosis in PCOS via negatively regulating insulin-stimulated AKT-FOXO3 pathway

Min Tan, Yanxiang Cheng, Xiaozhu Zhong, Dongyong Yang, Sushi Jiang, Yang Ye, Miao Ding, Guijun Guan, Dongzi Yang, Xiaomiao Zhao,
https://doi.org/10.18632/aging.202421 pp 4617—4633
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Identification of microRNA-16-5p and microRNA-21-5p in feces as potential noninvasive biomarkers for inflammatory bowel disease

Rui Zhou, Peishan Qiu, Haizhou Wang, Huijie Yang, Xueying Yang, Mingliang Ye, Fan Wang, Qiu Zhao,
https://doi.org/10.18632/aging.202428 pp 4634—4646
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Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis

Run-Ze Yang, Huo-Liang Zheng, Wen-Ning Xu, Xin-Feng Zheng, Bo Li, Lei-Sheng Jiang, Sheng-Dan Jiang,
https://doi.org/10.18632/aging.202506 pp 4647—4662
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Circular RNA circEPSTI1 accelerates cervical cancer progression via miR-375/409-3P/515-5p-SLC7A11 axis

Peng Wu, Chunxiang Li, Dong mei Ye, Kenan Yu, Yuxuan Li, Hailin Tang, Gaoshen Xu, Shuijing Yi, Zhiwei Zhang,
https://doi.org/10.18632/aging.202518 pp 4663—4673
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Integrated analysis of microRNA and mRNA expression profiling identifies BAIAP3 as a novel target of dysregulated hsa-miR-1972 in age-related white matter lesions

Wen-Qing Huang, Qing Lin, Shuai Chen, Lixiang Sun, Qingjie Chen, Kehui Yi, Zhi Li, Qilin Ma, Chi-Meng Tzeng,
https://doi.org/10.18632/aging.202562 pp 4674—4695
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Combined identification of ARID1A, CSMD1, and SENP3 as effective prognostic biomarkers for hepatocellular carcinoma

Yuanyuan Zhao, Bo Yang, Dong Chen, Xiaojun Zhou, Meixi Wang, Jipin Jiang, Lai Wei, Zhishui Chen,
https://doi.org/10.18632/aging.202586 pp 4696—4712
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Review

COVID-19
Neurological involvement in the respiratory manifestations of COVID-19 patients

Bai-Hong Tan, Jia-Mei Liu, Yue Gui, Shuang Wu, Jia-Le Suo, Yan-Chao Li,
https://doi.org/10.18632/aging.202665 pp 4713—4730
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Correction

Correction for: LncRNA PVT1 accelerates malignant phenotypes of bladder cancer cells by modulating miR-194-5p/BCLAF1 axis as a ceRNA

Mingwei Chen, Rongyuan Zhang, Le Lu, Jian Du, Chunyang Chen, Keke Ding, Xuedong Wei, Guangbo Zhang, Yuhua Huang, Jianquan Hou,
https://doi.org/10.18632/aging.202683 pp 4731—4733
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